ENSMUSG00000024556


Mus musculus

Features
Gene ID: ENSMUSG00000024556
  
Biological name :Me2
  
Synonyms : Me2 / NAD-dependent malic enzyme, mitochondrial / Q99KE1
  
Possible biological names infered from orthology : malic enzyme 2 / P23368
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E2
Gene start: 73770040
Gene end: 73815392
  
Corresponding Affymetrix probe sets: 10459730 (MoGene1.0st)   1426572_at (Mouse Genome 430 2.0 Array)   1426573_at (Mouse Genome 430 2.0 Array)   1458172_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025439
NCBI entrez gene - 107029     See in Manteia.
MGI - MGI:2147351
RefSeq - NM_145494
RefSeq - XM_006525496
RefSeq Peptide - NP_663469
swissprot - Q99KE1
Ensembl - ENSMUSG00000024556
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 me2ENSDARG00000100718Danio rerio
 ME2ENSG00000082212Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Me3 / Q8BMF3 / NADP-dependent malic enzyme, mitochondrial / Q16798* / malic enzyme 3*ENSMUSG0000003062153
Me1 / P06801 / NADP-dependent malic enzyme / P48163* / malic enzyme 1*ENSMUSG0000003241853


Protein motifs (from Interpro)
Interpro ID Name
 IPR001891  Malic oxidoreductase
 IPR012301  Malic enzyme, N-terminal domain
 IPR012302  Malic enzyme, NAD-binding
 IPR015884  Malic enzyme, conserved site
 IPR036291  NAD(P)-binding domain superfamily
 IPR037062  Malic enzyme, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006090 pyruvate metabolic process IBA
 biological_processGO:0006108 malate metabolic process IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902031 regulation of NADP metabolic process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004470 malic enzyme activity ISO
 molecular_functionGO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA
 molecular_functionGO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity IBA
 molecular_functionGO:0008948 oxaloacetate decarboxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024556 Me2 / Q99KE1 / NAD-dependent malic enzyme, mitochondrial / P23368* / malic enzyme 2*  / complex






 

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