ENSMUSG00000032418


Mus musculus

Features
Gene ID: ENSMUSG00000032418
  
Biological name :Me1
  
Synonyms : Me1 / NADP-dependent malic enzyme / P06801
  
Possible biological names infered from orthology : malic enzyme 1 / P48163
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.1
Gene start: 86581371
Gene end: 86695953
  
Corresponding Affymetrix probe sets: 10405753 (MoGene1.0st)   10595480 (MoGene1.0st)   1416632_at (Mouse Genome 430 2.0 Array)   1430307_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034989
Ensembl peptide - ENSMUSP00000140887
NCBI entrez gene - 17436     See in Manteia.
MGI - MGI:97043
RefSeq - XM_011242666
RefSeq - NM_001198933
RefSeq - NM_008615
RefSeq Peptide - NP_032641
RefSeq Peptide - NP_001185862
swissprot - P06801
swissprot - Q3TQP6
Ensembl - ENSMUSG00000032418
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 me1ENSDARG00000053215Danio rerio
 ME1ENSGALG00000015849Gallus gallus
 ME1ENSG00000065833Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Me3 / Q8BMF3 / NADP-dependent malic enzyme, mitochondrial / Q16798* / malic enzyme 3*ENSMUSG0000003062170
Me2 / Q99KE1 / NAD-dependent malic enzyme, mitochondrial / P23368* / malic enzyme 2*ENSMUSG0000002455655


Protein motifs (from Interpro)
Interpro ID Name
 IPR001891  Malic oxidoreductase
 IPR012301  Malic enzyme, N-terminal domain
 IPR012302  Malic enzyme, NAD-binding
 IPR015884  Malic enzyme, conserved site
 IPR036291  NAD(P)-binding domain superfamily
 IPR037062  Malic enzyme, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006090 pyruvate metabolic process IBA
 biological_processGO:0006108 malate metabolic process IEA
 biological_processGO:0009725 response to hormone ISS
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902031 regulation of NADP metabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0004470 malic enzyme activity IEA
 molecular_functionGO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity IEA
 molecular_functionGO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008948 oxaloacetate decarboxylase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: A/A,Mc1rE-tob/Mc1rE-tob
Genetic Background: M. m. domesticus poschiavinus

Allelic Composition: Me1n/Me1+
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032418 Me1 / P06801 / NADP-dependent malic enzyme / P48163* / malic enzyme 1*  / complex






 

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