ENSG00000090339


Homo sapiens

Features
Gene ID: ENSG00000090339
  
Biological name :ICAM1
  
Synonyms : ICAM1 / intercellular adhesion molecule 1 / P05362
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.2
Gene start: 10270835
Gene end: 10286615
  
Corresponding Affymetrix probe sets: 202637_s_at (Human Genome U133 Plus 2.0 Array)   202638_s_at (Human Genome U133 Plus 2.0 Array)   215485_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413124
Ensembl peptide - ENSP00000465680
Ensembl peptide - ENSP00000264832
NCBI entrez gene - 3383     See in Manteia.
OMIM - 147840
RefSeq - NM_000201
RefSeq Peptide - NP_000192
swissprot - E7ESS4
swissprot - K7EKL8
swissprot - P05362
Ensembl - ENSG00000090339
  
Related genetic diseases (OMIM): 611162 - {Malaria, cerebral, susceptibility to}, 611162
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Icam1ENSMUSG00000037405Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ICAM3 / P32942 / intercellular adhesion molecule 3ENSG0000007666246
ICAM5 / Q9UMF0 / intercellular adhesion molecule 5ENSG0000010537645
ICAM2 / P13598 / intercellular adhesion molecule 2ENSG0000010862215
ICAM4 / Q14773 / intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)ENSG000001053719


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR003987  Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
 IPR003988  Intercellular adhesion molecule
 IPR013768  Intercellular adhesion molecule, N-terminal
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001910 regulation of leukocyte mediated cytotoxicity TAS
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0002457 T cell antigen processing and presentation IEA
 biological_processGO:0002693 positive regulation of cellular extravasation IMP
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS
 biological_processGO:0007159 leukocyte cell-cell adhesion IMP
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010477 response to sulfur dioxide IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0022614 membrane to membrane docking IEP
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0031669 cellular response to nutrient levels IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0034698 response to gonadotropin IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0044406 adhesion of symbiont to host IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046813 receptor-mediated virion attachment to host cell IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050900 leukocyte migration IEP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051926 negative regulation of calcium ion transport IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0061028 establishment of endothelial barrier IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0090557 establishment of endothelial intestinal barrier IEA
 biological_processGO:0097368 establishment of Sertoli cell barrier IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1900027 regulation of ruffle assembly IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IDA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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