ENSMUSG00000037405


Mus musculus

Features
Gene ID: ENSMUSG00000037405
  
Biological name :Icam1
  
Synonyms : Icam1 / intercellular adhesion molecule 1 / P13597
  
Possible biological names infered from orthology : P05362
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A3
Gene start: 21015985
Gene end: 21028817
  
Corresponding Affymetrix probe sets: 10583519 (MoGene1.0st)   1424067_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083587
NCBI entrez gene - 15894     See in Manteia.
MGI - MGI:96392
RefSeq - NM_010493
RefSeq Peptide - NP_034623
swissprot - P13597
swissprot - Q3U8M7
Ensembl - ENSMUSG00000037405
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ICAM1ENSG00000090339Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Icam5 / Q60625 / Intercellular adhesion molecule 5 / Q9UMF0*ENSMUSG0000003217439
Tcam1 / testicular cell adhesion molecule 1ENSMUSG0000002071232
Icam2 / P35330 / Intercellular adhesion molecule 2 / P13598*ENSMUSG0000000102915
Icam4 / Q9ERM2 / Intercellular adhesion molecule 4 / Q14773* / intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)*ENSMUSG0000000101412


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR003987  Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal
 IPR003988  Intercellular adhesion molecule
 IPR007110  Immunoglobulin-like domain
 IPR013768  Intercellular adhesion molecule, N-terminal
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IEA
 biological_processGO:0002457 T cell antigen processing and presentation IDA
 biological_processGO:0002693 positive regulation of cellular extravasation IEA
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0022614 membrane to membrane docking IEA
 biological_processGO:0030155 regulation of cell adhesion IDA
 biological_processGO:0033627 cell adhesion mediated by integrin IDA
 biological_processGO:0044406 adhesion of symbiont to host IEA
 biological_processGO:0046813 receptor-mediated virion attachment to host cell IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0061028 establishment of endothelial barrier IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071333 cellular response to glucose stimulus IDA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1900027 regulation of ruffle assembly IDA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005178 integrin binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Integrin cell surface interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Prkdcscid/Prkdcscid
Genetic Background: NOD.Cg-B2mtm1Unc Prkdcscid

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: either: B6.129S7-Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Icam1tm1Alb/Icam1tm1Alb
Genetic Background: B6.Cg-Icam1tm1Alb

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Spta1sph-ha/Spta1sph-ha
Genetic Background: either:(B6.D1-Spta1sph-ha x WB.D1-Spta1sph-ha)F1 or (WB.D1-Spta1sph-ha x B6.D1-Spta1sph-ha)F1

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppiftm1.1Mmos/Ppif+
Genetic Background: involves: 129X1/SvJ * FVB/NJ

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aqp2tm1(AQP2)Suc/Aqp2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003434 resistance to induced choroidal neovascularization "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0003627 abnormal lymphocyte rolling "anomaly in the number or velocity of lymphocytes rolling along the luminal aspects of high endothelial venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Icam1tm1Alb/Icam1tm1Alb
Genetic Background: B6.Cg-Icam1tm1Alb

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: either: B6.129S7-Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Icam1tm1Alb/Icam1tm1Alb
Genetic Background: B6.Cg-Icam1tm1Alb

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Faslpr Tg(INS-Il10)#Sar

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Ldlrtm1Her/Ldlrtm1Her,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0005580 periinsulitis "early pancreatic infiltration of mononuclear cells around pancreatic Langerhans islets" [J:11442, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Tg(INS-Il10)#Sar/0
Genetic Background: NOD.Cg-Faslpr Tg(INS-Il10)#Sar

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Seletm2Alb/Seletm2Alb,Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: B6.129P2-Selltm1Tft

 MP:0011825 decreased cell chemotaxis "reduciton in the directed movement response of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [MGI:csmith]
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Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1tm1Dmil
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Icam1tm1Jcgr/Icam1tm1Jcgr,Vcam1tm1Dmil/Vcam1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012194 decreased keratinocyte migration "reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selltm1Tft/Selltm1Tft
Genetic Background: B6.129-Selltm1Tft Icam1tm1Bay

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Icam1tm1Bay/Icam1tm1Bay,Selptm1Bay/Selptm1Bay
Genetic Background: either: B6.129S7-Selptm1Bay Icam1tm1Bay or (involves: 129S7/SvEvBrd * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030830 Itgal / P24063 / Integrin alpha-L / P20701* / integrin subunit alpha L*  / complex / reaction






 

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