ENSG00000100116


Homo sapiens

Features
Gene ID: ENSG00000100116
  
Biological name :GCAT
  
Synonyms : GCAT / glycine C-acetyltransferase / O75600
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 37807905
Gene end: 37817176
  
Corresponding Affymetrix probe sets: 205164_at (Human Genome U133 Plus 2.0 Array)   36475_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000248924
Ensembl peptide - ENSP00000388151
Ensembl peptide - ENSP00000402213
Ensembl peptide - ENSP00000406719
Ensembl peptide - ENSP00000371110
NCBI entrez gene - 23464     See in Manteia.
OMIM - 607422
RefSeq - XM_017028677
RefSeq - XM_005261410
RefSeq - XM_005261411
RefSeq - XM_011530023
RefSeq - XM_017028674
RefSeq - XM_017028675
RefSeq - XM_017028676
RefSeq - NM_001171690
RefSeq - NM_014291
RefSeq - XM_005261409
RefSeq Peptide - NP_001165161
RefSeq Peptide - NP_055106
swissprot - F2Z340
swissprot - H7BZ75
swissprot - O75600
swissprot - C9IZC9
Ensembl - ENSG00000100116
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gcatENSDARG00000005643Danio rerio
 GCATENSGALG00000012312Gallus gallus
 GcatENSMUSG00000006378Mus musculus
 GcatENSMUSG00000116378Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ALAS2 / P22557 / 5-aminolevulinate synthase 2ENSG0000015857830
ALAS1 / P13196 / 5-aminolevulinate synthase 1ENSG0000002333029


Protein motifs (from Interpro)
Interpro ID Name
 IPR001917  Aminotransferase, class-II, pyridoxal-phosphate binding site
 IPR004839  Aminotransferase, class I/classII
 IPR011282  2-amino-3-ketobutyrate coenzyme A ligase
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006520 cellular amino acid metabolic process NAS
 biological_processGO:0006567 threonine catabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0019518 L-threonine catabolic process to glycine TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008890 glycine C-acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA


Pathways (from Reactome)
Pathway description
Threonine catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100116 GCAT / O75600 / glycine C-acetyltransferase  / complex






 

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