ENSG00000101367


Homo sapiens

Features
Gene ID: ENSG00000101367
  
Biological name :MAPRE1
  
Synonyms : MAPRE1 / microtubule associated protein RP/EB family member 1 / Q15691
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.21
Gene start: 32819893
Gene end: 32850405
  
Corresponding Affymetrix probe sets: 200712_s_at (Human Genome U133 Plus 2.0 Array)   200713_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364721
NCBI entrez gene - 22919     See in Manteia.
OMIM - 603108
RefSeq - NM_012325
RefSeq - XM_011528696
RefSeq Peptide - NP_036457
swissprot - Q15691
Ensembl - ENSG00000101367
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapre1aENSDARG00000042927Danio rerio
 mapre1bENSDARG00000002659Danio rerio
 MAPRE1ENSGALG00000006657Gallus gallus
 Mapre1ENSMUSG00000027479Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPRE3 / Q9UPY8 / microtubule associated protein RP/EB family member 3ENSG0000008476466
MAPRE2 / Q15555 / microtubule associated protein RP/EB family member 2ENSG0000016697459


Protein motifs (from Interpro)
Interpro ID Name
 IPR001715  Calponin homology domain
 IPR004953  EB1, C-terminal
 IPR027328  Microtubule-associated protein RP/EB
 IPR027739  EB1, Metazoa
 IPR036133  EB1, C-terminal domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0008104 protein localization TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0030335 positive regulation of cell migration TAS
 biological_processGO:0031115 negative regulation of microtubule polymerization IDA
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0035372 protein localization to microtubule IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1903033 positive regulation of microtubule plus-end binding IEA
 biological_processGO:1904527 negative regulation of microtubule binding TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0030981 cortical microtubule cytoskeleton IDA
 cellular_componentGO:0031253 cell projection membrane IEA
 cellular_componentGO:0035371 microtubule plus-end IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008022 protein C-terminus binding TAS
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051010 microtubule plus-end binding IDA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101367 MAPRE1 / Q15691 / microtubule associated protein RP/EB family member 1  / complex
 ENSG00000075218 GTSE1 / Q9NYZ3 / G2 and S-phase expressed 1  / reaction / complex






 

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