ENSG00000104408


Homo sapiens

Features
Gene ID: ENSG00000104408
  
Biological name :EIF3E
  
Synonyms : EIF3E / eukaryotic translation initiation factor 3 subunit E / P60228
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q23.1
Gene start: 108201216
Gene end: 108435333
  
Corresponding Affymetrix probe sets: 208697_s_at (Human Genome U133 Plus 2.0 Array)   235429_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428796
Ensembl peptide - ENSP00000430839
Ensembl peptide - ENSP00000430709
Ensembl peptide - ENSP00000430678
Ensembl peptide - ENSP00000430649
Ensembl peptide - ENSP00000430152
Ensembl peptide - ENSP00000429968
Ensembl peptide - ENSP00000429327
Ensembl peptide - ENSP00000220849
Ensembl peptide - ENSP00000428170
NCBI entrez gene - 3646     See in Manteia.
OMIM - 602210
RefSeq - NM_001568
RefSeq - XM_017013398
RefSeq Peptide - NP_001559
swissprot - E5RHS5
swissprot - E5RGA2
swissprot - E5RJ25
swissprot - H0YBP5
swissprot - H0YBR5
swissprot - P60228
swissprot - H0YAW4
swissprot - E5RIT4
swissprot - E5RIP5
swissprot - E5RII3
Ensembl - ENSG00000104408
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif3eaENSDARG00000090697Danio rerio
 eif3ebENSDARG00000002549Danio rerio
 EIF3EENSGALG00000037067Gallus gallus
 Eif3eENSMUSG00000022336Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR016650  Eukaryotic translation initiation factor 3 subunit E
 IPR019010  Eukaryotic translation initiation factor 3 subunit E, N-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
 biological_processGO:0001732 formation of cytoplasmic translation initiation complex IEA
 biological_processGO:0002183 cytoplasmic translational initiation IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006446 regulation of translational initiation NAS
 biological_processGO:0045727 positive regulation of translation IPI
 biological_processGO:0045947 negative regulation of translational initiation NAS
 biological_processGO:1902416 positive regulation of mRNA binding IPI
 cellular_componentGO:0000785 chromatin NAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005852 eukaryotic translation initiation factor 3 complex IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016282 eukaryotic 43S preinitiation complex IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0033290 eukaryotic 48S preinitiation complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0047485 protein N-terminus binding IPI


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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