ENSG00000104755


Homo sapiens

Features
Gene ID: ENSG00000104755
  
Biological name :ADAM2
  
Synonyms : ADAM2 / ADAM metallopeptidase domain 2 / Q99965
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p11.22
Gene start: 39743735
Gene end: 39838289
  
Corresponding Affymetrix probe sets: 207664_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265708
Ensembl peptide - ENSP00000369182
Ensembl peptide - ENSP00000429352
Ensembl peptide - ENSP00000483607
Ensembl peptide - ENSP00000343854
NCBI entrez gene - 2515     See in Manteia.
OMIM - 601533
RefSeq - XM_011544480
RefSeq - NM_001278113
RefSeq - NM_001278114
RefSeq - NM_001464
RefSeq - XM_005273468
RefSeq - XM_011544479
RefSeq Peptide - NP_001455
RefSeq Peptide - NP_001265042
RefSeq Peptide - NP_001265043
swissprot - Q6P2G0
swissprot - Q99965
swissprot - B4DWY7
Ensembl - ENSG00000104755
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174164ENSDARG00000057138Danio rerio
 ENSGALG00000044168Gallus gallus
 ENSGALG00000044866Gallus gallus
 Adam2ENSMUSG00000022039Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM32 / Q8TC27 / ADAM metallopeptidase domain 32ENSG0000019714041
ADAM18 / Q9Y3Q7 / ADAM metallopeptidase domain 18ENSG0000016861940
ADAM9 / Q13443 / ADAM metallopeptidase domain 9ENSG0000016861533
ADAM30 / Q9UKF2 / ADAM metallopeptidase domain 30ENSG0000013424930
ADAM21 / Q9UKJ8 / ADAM metallopeptidase domain 21ENSG0000013998527
ADAM29 / Q9UKF5 / ADAM metallopeptidase domain 29ENSG0000016859426
ADAM20 / O43506 / ADAM metallopeptidase domain 20ENSG0000013400726


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR033958  ADAM2 protein
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IEA
 biological_processGO:0007338 single fertilization IEA
 biological_processGO:0007339 binding of sperm to zona pellucida TAS
 biological_processGO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization TAS
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030534 adult behavior IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005178 integrin binding TAS
 molecular_functionGO:0008237 metallopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086062 P15291 / B4GALT1 / beta-1,4-galactosyltransferase 1  / complex / reaction
 ENSG00000134007 ADAM20 / O43506 / ADAM metallopeptidase domain 20  / complex
 ENSG00000134249 ADAM30 / Q9UKF2 / ADAM metallopeptidase domain 30  / complex
 ENSG00000139985 ADAM21 / Q9UKJ8 / ADAM metallopeptidase domain 21  / complex






 

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