ENSG00000139985


Homo sapiens

Features
Gene ID: ENSG00000139985
  
Biological name :ADAM21
  
Synonyms : ADAM21 / ADAM metallopeptidase domain 21 / Q9UKJ8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q24.2
Gene start: 70452157
Gene end: 70459899
  
Corresponding Affymetrix probe sets: 1552579_a_at (Human Genome U133 Plus 2.0 Array)   207665_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474385
NCBI entrez gene - 8747     See in Manteia.
OMIM - 603713
RefSeq - NM_003813
RefSeq Peptide - NP_003804
swissprot - Q9UKJ8
Ensembl - ENSG00000139985
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174164ENSDARG00000057138Danio rerio
 ENSGALG00000013838Gallus gallus
 Adam21ENSMUSG00000008438Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM20 / O43506 / ADAM metallopeptidase domain 20ENSG0000013400761
ADAM29 / Q9UKF5 / ADAM metallopeptidase domain 29ENSG0000016859449
ADAM30 / Q9UKF2 / ADAM metallopeptidase domain 30ENSG0000013424938
ADAM9 / Q13443 / ADAM metallopeptidase domain 9ENSG0000016861535
ADAM2 / Q99965 / ADAM metallopeptidase domain 2ENSG0000010475528
ADAM32 / Q8TC27 / ADAM metallopeptidase domain 32ENSG0000019714027
ADAM18 / Q9Y3Q7 / ADAM metallopeptidase domain 18ENSG0000016861927


Protein motifs (from Interpro)
Interpro ID Name
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007338 single fertilization TAS
 biological_processGO:0007339 binding of sperm to zona pellucida TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086062 P15291 / B4GALT1 / beta-1,4-galactosyltransferase 1  / complex / reaction
 ENSG00000134007 ADAM20 / O43506 / ADAM metallopeptidase domain 20  / complex
 ENSG00000134249 ADAM30 / Q9UKF2 / ADAM metallopeptidase domain 30  / complex
 ENSG00000104755 ADAM2 / Q99965 / ADAM metallopeptidase domain 2  / complex






 

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