ENSG00000134249


Homo sapiens

Features
Gene ID: ENSG00000134249
  
Biological name :ADAM30
  
Synonyms : ADAM30 / ADAM metallopeptidase domain 30 / Q9UKF2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p12
Gene start: 119893533
Gene end: 119896495
  
Corresponding Affymetrix probe sets: 221446_at (Human Genome U133 Plus 2.0 Array)   243520_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358407
NCBI entrez gene - 11085     See in Manteia.
OMIM - 604779
RefSeq - NM_021794
RefSeq Peptide - NP_068566
swissprot - Q9UKF2
Ensembl - ENSG00000134249
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174164ENSDARG00000057138Danio rerio
 ENSGALG00000013838Gallus gallus
 Adam30ENSMUSG00000043468Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADAM21 / Q9UKJ8 / ADAM metallopeptidase domain 21ENSG0000013998535
ADAM9 / Q13443 / ADAM metallopeptidase domain 9ENSG0000016861534
ADAM20 / O43506 / ADAM metallopeptidase domain 20ENSG0000013400733
ADAM29 / Q9UKF5 / ADAM metallopeptidase domain 29ENSG0000016859432
ADAM2 / Q99965 / ADAM metallopeptidase domain 2ENSG0000010475528
ADAM32 / Q8TC27 / ADAM metallopeptidase domain 32ENSG0000019714026
ADAM18 / Q9Y3Q7 / ADAM metallopeptidase domain 18ENSG0000016861925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007339 binding of sperm to zona pellucida TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:1990913 sperm head plasma membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity TAS
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interaction With The Zona Pellucida


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134007 ADAM20 / O43506 / ADAM metallopeptidase domain 20  / complex
 ENSG00000104755 ADAM2 / Q99965 / ADAM metallopeptidase domain 2  / complex
 ENSG00000086062 P15291 / B4GALT1 / beta-1,4-galactosyltransferase 1  / reaction / complex
 ENSG00000139985 ADAM21 / Q9UKJ8 / ADAM metallopeptidase domain 21  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr