ENSG00000108684


Homo sapiens

Features
Gene ID: ENSG00000108684
  
Biological name :ASIC2
  
Synonyms : acid sensing ion channel subunit 2 / ASIC2 / Q16515
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 33013087
Gene end: 34174964
  
Corresponding Affymetrix probe sets: 206690_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000225823
Ensembl peptide - ENSP00000352934
NCBI entrez gene - 40     See in Manteia.
OMIM - 601784
RefSeq - NM_001094
RefSeq - NM_183377
RefSeq Peptide - NP_001085
RefSeq Peptide - NP_899233
swissprot - Q16515
Ensembl - ENSG00000108684
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asic2ENSDARG00000006849Danio rerio
 ASIC2ENSGALG00000000367Gallus gallus
 Asic2ENSMUSG00000020704Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ASIC1 / P78348 / acid sensing ion channel subunit 1ENSG0000011088155
ASIC3 / Q9UHC3 / acid sensing ion channel subunit 3ENSG0000021319942
ASIC4 / Q96FT7 / acid sensing ion channel subunit family member 4ENSG0000007218240
ASIC5 / Q9NY37 / acid sensing ion channel subunit family member 5ENSG0000025639423
P51168 / SCNN1B / sodium channel epithelial 1 beta subunitENSG0000016844722
P51170 / SCNN1G / sodium channel epithelial 1 gamma subunitENSG0000016682821
P51172 / SCNN1D / sodium channel epithelial 1 delta subunitENSG0000016257221
P37088 / SCNN1A / sodium channel epithelial 1 alpha subunitENSG0000011131920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001873  Epithelial sodium channel
 IPR004724  Epithelial sodium channel, chordates
 IPR020903  Epithelial sodium channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003026 regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007422 peripheral nervous system development TAS
 biological_processGO:0007602 phototransduction IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010447 response to acidic pH IEA
 biological_processGO:0015672 monovalent inorganic cation transport TAS
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035418 protein localization to synapse IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0050915 sensory perception of sour taste IMP
 biological_processGO:0050974 detection of mechanical stimulus involved in sensory perception IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015280 ligand-gated sodium channel activity TAS
 molecular_functionGO:0022839 ion gated channel activity IEA
 molecular_functionGO:0044736 acid-sensing ion channel activity TAS


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108684 ASIC2 / Q16515 / acid sensing ion channel subunit 2  / complex
 ENSG00000133115 Q8TAV4 / STOML3 / stomatin like 3  / complex / reaction






 

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