ENSG00000110881


Homo sapiens

Features
Gene ID: ENSG00000110881
  
Biological name :ASIC1
  
Synonyms : acid sensing ion channel subunit 1 / ASIC1 / P78348
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.12
Gene start: 50057548
Gene end: 50083611
  
Corresponding Affymetrix probe sets: 205156_s_at (Human Genome U133 Plus 2.0 Array)   37953_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450247
Ensembl peptide - ENSP00000446863
Ensembl peptide - ENSP00000448263
Ensembl peptide - ENSP00000228468
Ensembl peptide - ENSP00000400228
Ensembl peptide - ENSP00000402896
NCBI entrez gene - 41     See in Manteia.
OMIM - 602866
RefSeq - XM_011538352
RefSeq - NM_001095
RefSeq - NM_001256830
RefSeq - NM_020039
RefSeq - XM_011538350
RefSeq - XM_011538351
RefSeq Peptide - NP_064423
RefSeq Peptide - NP_001243759
RefSeq Peptide - NP_001086
swissprot - F8VSK4
swissprot - H7C1W9
swissprot - H0YHD6
swissprot - P78348
Ensembl - ENSG00000110881
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asic1aENSDARG00000008329Danio rerio
 si:dkey-57c15.1ENSDARG00000105115Danio rerio
 ASIC1ENSGALG00000034025Gallus gallus
 Asic1ENSMUSG00000023017Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ASIC2 / Q16515 / acid sensing ion channel subunit 2ENSG0000010868454
ASIC4 / Q96FT7 / acid sensing ion channel subunit family member 4ENSG0000007218244
ASIC3 / Q9UHC3 / acid sensing ion channel subunit 3ENSG0000021319944
ASIC5 / Q9NY37 / acid sensing ion channel subunit family member 5ENSG0000025639425
P51170 / SCNN1G / sodium channel epithelial 1 gamma subunitENSG0000016682822
P51168 / SCNN1B / sodium channel epithelial 1 beta subunitENSG0000016844722
P51172 / SCNN1D / sodium channel epithelial 1 delta subunitENSG0000016257221
P37088 / SCNN1A / sodium channel epithelial 1 alpha subunitENSG0000011131921


Protein motifs (from Interpro)
Interpro ID Name
 IPR001873  Epithelial sodium channel
 IPR004724  Epithelial sodium channel, chordates
 IPR020903  Epithelial sodium channel, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007613 memory IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0009268 response to pH TAS
 biological_processGO:0010447 response to acidic pH IEA
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0046929 negative regulation of neurotransmitter secretion IEA
 biological_processGO:0050915 sensory perception of sour taste IMP
 biological_processGO:0070207 protein homotrimerization ISS
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071467 cellular response to pH IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015280 ligand-gated sodium channel activity TAS
 molecular_functionGO:0022839 ion gated channel activity IEA
 molecular_functionGO:0044736 acid-sensing ion channel activity TAS


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110881 ASIC1 / P78348 / acid sensing ion channel subunit 1  / complex
 ENSG00000133115 Q8TAV4 / STOML3 / stomatin like 3  / complex / reaction






 

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