ENSG00000109610


Homo sapiens

Features
Gene ID: ENSG00000109610
  
Biological name :SOD3
  
Synonyms : P08294 / SOD3 / superoxide dismutase 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: p15.2
Gene start: 24789912
Gene end: 24800842
  
Corresponding Affymetrix probe sets: 205236_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000371554
Ensembl peptide - ENSP00000472134
NCBI entrez gene - 6649     See in Manteia.
OMIM - 185490
RefSeq - NM_003102
RefSeq Peptide - NP_003093
swissprot - A0A140VJU8
swissprot - M0R1V4
swissprot - P08294
Ensembl - ENSG00000109610
  
Related genetic diseases (OMIM): 185490 - [Superoxide dismutase, elevated extracellular]
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sod3aENSDARG00000070168Danio rerio
 sod3bENSDARG00000079183Danio rerio
 SOD3ENSGALG00000018557Gallus gallus
 Sod3ENSMUSG00000072941Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCS / O14618 / copper chaperone for superoxide dismutaseENSG0000017399223
SOD1 / P00441 / superoxide dismutase 1ENSG0000014216823


Protein motifs (from Interpro)
Interpro ID Name
 IPR001424  Superoxide dismutase, copper/zinc binding domain
 IPR018152  Superoxide dismutase, copper/zinc, binding site
 IPR024134  Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
 IPR036423  Superoxide dismutase-like, copper/zinc binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004784 superoxide dismutase activity IBA
 molecular_functionGO:0005507 copper ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109610 SOD3 / P08294 / superoxide dismutase 3  / complex






 

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