ENSG00000173992


Homo sapiens

Features
Gene ID: ENSG00000173992
  
Biological name :CCS
  
Synonyms : CCS / copper chaperone for superoxide dismutase / O14618
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.2
Gene start: 66592821
Gene end: 66606019
  
Corresponding Affymetrix probe sets: 203522_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433609
Ensembl peptide - ENSP00000436379
Ensembl peptide - ENSP00000436318
Ensembl peptide - ENSP00000307870
NCBI entrez gene - 9973     See in Manteia.
OMIM - 603864
RefSeq - NM_005125
RefSeq Peptide - NP_005116
swissprot - E9PP76
swissprot - E9PK03
swissprot - J3KNF4
swissprot - O14618
Ensembl - ENSG00000173992
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccsENSDARG00000092003Danio rerio
 ccsENSDARG00000116246Danio rerio
 CcsENSMUSG00000034108Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SOD1 / P00441 / superoxide dismutase 1ENSG0000014216827
SOD3 / P08294 / superoxide dismutase 3ENSG0000010961020


Protein motifs (from Interpro)
Interpro ID Name
 IPR001424  Superoxide dismutase, copper/zinc binding domain
 IPR006121  Heavy metal-associated domain, HMA
 IPR018152  Superoxide dismutase, copper/zinc, binding site
 IPR024134  Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
 IPR036163  Heavy metal-associated domain superfamily
 IPR036423  Superoxide dismutase-like, copper/zinc binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0015680 intracellular copper ion transport TAS
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0051353 positive regulation of oxidoreductase activity IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004784 superoxide dismutase activity IEA
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0015035 protein disulfide oxidoreductase activity TAS
 molecular_functionGO:0016532 superoxide dismutase copper chaperone activity IBA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173992 CCS / O14618 / copper chaperone for superoxide dismutase  / complex / reaction
 ENSG00000142168 SOD1 / P00441 / superoxide dismutase 1  / reaction / complex






 

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