ENSMUSG00000034108


Mus musculus

Features
Gene ID: ENSMUSG00000034108
  
Biological name :Ccs
  
Synonyms : Ccs / Copper chaperone for superoxide dismutase / Q9WU84
  
Possible biological names infered from orthology : O14618
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 4825366
Gene end: 4839322
  
Corresponding Affymetrix probe sets: 10464825 (MoGene1.0st)   1448615_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035486
NCBI entrez gene - 12460     See in Manteia.
MGI - MGI:1333783
RefSeq - XM_006531645
RefSeq - NM_016892
RefSeq Peptide - NP_058588
swissprot - Q543K2
swissprot - Q9WU84
Ensembl - ENSMUSG00000034108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccsENSDARG00000092003Danio rerio
 ccsENSDARG00000116246Danio rerio
 CCSENSG00000173992Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sod1 / P08228 / Superoxide dismutase [Cu-Zn] / P00441* / superoxide dismutase 1*ENSMUSG0000002298228
Sod3 / O09164 / superoxide dismutase 3, extracellular / P08294* / superoxide dismutase 3*ENSMUSG0000007294118


Protein motifs (from Interpro)
Interpro ID Name
 IPR001424  Superoxide dismutase, copper/zinc binding domain
 IPR006121  Heavy metal-associated domain, HMA
 IPR018152  Superoxide dismutase, copper/zinc, binding site
 IPR024134  Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
 IPR036163  Heavy metal-associated domain superfamily
 IPR036423  Superoxide dismutase-like, copper/zinc binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0030001 metal ion transport IEA
 biological_processGO:0051353 positive regulation of oxidoreductase activity IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005758 mitochondrial intermembrane space TAS
 molecular_functionGO:0004784 superoxide dismutase activity IEA
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016532 superoxide dismutase copper chaperone activity IBA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0003951 abnormal copper homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in a number of proteins including amine oxidases and chaperone proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022982 Sod1 / P08228 / Superoxide dismutase [Cu-Zn] / P00441* / superoxide dismutase 1*  / reaction / complex
 ENSMUSG00000034108 Ccs / Q9WU84 / Copper chaperone for superoxide dismutase / O14618*  / complex / reaction






 

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