ENSMUSG00000022982


Mus musculus

Features
Gene ID: ENSMUSG00000022982
  
Biological name :Sod1
  
Synonyms : P08228 / Sod1 / Superoxide dismutase [Cu-Zn]
  
Possible biological names infered from orthology : P00441 / superoxide dismutase 1
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 90220742
Gene end: 90226322
  
Corresponding Affymetrix probe sets: 10436783 (MoGene1.0st)   1435304_at (Mouse Genome 430 2.0 Array)   1440222_at (Mouse Genome 430 2.0 Array)   1447761_x_at (Mouse Genome 430 2.0 Array)   1451124_at (Mouse Genome 430 2.0 Array)   1459976_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023707
NCBI entrez gene - 20655     See in Manteia.
MGI - MGI:98351
RefSeq - NM_011434
RefSeq Peptide - NP_035564
swissprot - P08228
Ensembl - ENSMUSG00000022982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sod1ENSDARG00000043848Danio rerio
 SOD1ENSGALG00000015844Gallus gallus
 SOD1ENSG00000142168Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccs / Q9WU84 / Copper chaperone for superoxide dismutase / O14618*ENSMUSG0000003410849
Sod3 / O09164 / superoxide dismutase 3, extracellular / P08294* / superoxide dismutase 3*ENSMUSG0000007294136


Protein motifs (from Interpro)
Interpro ID Name
 IPR001424  Superoxide dismutase, copper/zinc binding domain
 IPR018152  Superoxide dismutase, copper/zinc, binding site
 IPR024134  Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
 IPR036423  Superoxide dismutase-like, copper/zinc binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0000302 response to reactive oxygen species IMP
 biological_processGO:0000303 response to superoxide IEA
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001895 retina homeostasis IMP
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0002262 myeloid cell homeostasis IMP
 biological_processGO:0006749 glutathione metabolic process IMP
 biological_processGO:0006801 superoxide metabolic process ISO
 biological_processGO:0006879 cellular iron ion homeostasis IMP
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007566 embryo implantation IMP
 biological_processGO:0007568 aging IMP
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008089 anterograde axonal transport IMP
 biological_processGO:0008090 retrograde axonal transport IMP
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0009408 response to heat IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0019226 transmission of nerve impulse IMP
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032287 peripheral nervous system myelin maintenance IMP
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0034465 response to carbon monoxide IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0035865 cellular response to potassium ion IEA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0042542 response to hydrogen peroxide IMP
 biological_processGO:0042554 superoxide anion generation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045471 response to ethanol IMP
 biological_processGO:0045541 negative regulation of cholesterol biosynthetic process IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0046716 muscle cell cellular homeostasis IMP
 biological_processGO:0048678 response to axon injury IMP
 biological_processGO:0050665 hydrogen peroxide biosynthetic process IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060047 heart contraction IEA
 biological_processGO:0060052 neurofilament cytoskeleton organization IMP
 biological_processGO:0060087 relaxation of vascular smooth muscle IMP
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071318 cellular response to ATP IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0097332 response to antipsychotic drug IEA
 biological_processGO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space TAS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031045 dense core granule IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0004784 superoxide dismutase activity TAS
 molecular_functionGO:0005507 copper ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030346 protein phosphatase 2B binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA
 molecular_functionGO:0051087 chaperone binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jag1tm1Grid/Jag1tm2Grid,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Zfpm1tm1Sho/Zfpm1tm1Sho
Genetic Background: involves: 129S1/Sv

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001749 suppressed circulating follicle stimulating hormone level "repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:45065, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Hmox1tm1Ysh/Hmox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hmox1tm1Ysh/Hmox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0004362 cochlear hair cell degeneration "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004364 thin stria vascularis "reduced thickness of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sod1tm1Cep/Sod1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sod1tm1Cep/Sod1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004586 pillar cell degeneration "degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004597 increased susceptibility to noise-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004748 increased susceptibility to age-related hearing loss "greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sod1tm1Cep/Sod1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0004818 increased skeletal muscle mass "increase in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005097 polychromatophilia "condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005251 blepharitis "inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005252 abnormal meibomian gland morphology "structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005356 positive geotaxis "mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0005498 hyporesponsive to tactile stimuli "reduced reflex action normally induced by touch or pain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: Adamts20bt-2H/Adamts20bt-2H,Kittm1Alf/Kit+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006303 abnormal retinal nerve fiber layer morphology "malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Cry1tm1Jhjh/Cry1tm1Jhjh,Cry2tm1Jhjh/Cry2tm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fancctm1Mab/Fancctm1Mab,Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0009421 increased gastrocnemius weight "increase in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0009423 increased extensor digitorum longus weight "increase in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0009425 increased soleus weight "increase in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0009427 increased tibialis anterior weight "increase in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1Ysh/Hmox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hmox1tm1Ysh/Hmox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009935 abnormal meibomian gland acinus morphology "anomalies of the sac-like structures comprising the sebaceous glands located at the rim of the eyelids and responsible for producing sebum" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fancctm1Mab/Fancctm1Mab,Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010226 increased quadriceps weight "increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb1tm14.1Ref/Itgb1tm15.1Ref
Genetic Background: Not Specified

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0011632 dilated mitochondria "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sod1tm1Cep/Sod1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Lhx1tm1Bhr/Lhx1tm1Tmj
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sod1tm1Cep/Sod1tm1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Sod1tm1Cep/Sod1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0012320 abnormal body fat mass "aberrant fat-containing physical bulk or volume of the body" [MPD:Molly]
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Allelic Composition: Ryr1m1Nisw/Ryr1+
Genetic Background: 129S1.B6-Ryr1m1Nisw

 MP:0013391 abnormal Meibomian gland physiology "any functional anomaly of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate; dysfunctional Meibomian glands may produce an excessive amount of oil, cause dry eyes, or contribute to blepharitis" [MGI:Anna]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013392 Meibomian gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate; chronic Meibomian gland inflammation can lead to a lump in the eyelid known as a Meibomian gland cyst (aka chalazion)" [MGI:Anna]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Ins2Akita/Ins2Akita
Genetic Background: C57BL/6-Ins2Akita/J

 MP:0020218 abnormal tear production "an anomaly in the amount of fluid produced in the eye" [GOC:NV]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0020220 decreased tear production "decreased production of the amount of fluid produced in the eye" [GOC:NV]
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Allelic Composition: Sod1tm1Leb/Sod1tm1Leb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022982 Sod1 / P08228 / Superoxide dismutase [Cu-Zn] / P00441* / superoxide dismutase 1*  / complex / reaction
 ENSMUSG00000034108 Ccs / Q9WU84 / Copper chaperone for superoxide dismutase / O14618*  / reaction / complex






 

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