ENSMUSG00000072941


Mus musculus

Features
Gene ID: ENSMUSG00000072941
  
Biological name :Sod3
  
Synonyms : O09164 / Sod3 / superoxide dismutase 3, extracellular
  
Possible biological names infered from orthology : P08294 / superoxide dismutase 3
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: C1
Gene start: 52363791
Gene end: 52371418
  
Corresponding Affymetrix probe sets: 10521824 (MoGene1.0st)   1417633_at (Mouse Genome 430 2.0 Array)   1417634_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098768
NCBI entrez gene - 20657     See in Manteia.
MGI - MGI:103181
RefSeq - NM_011435
RefSeq Peptide - NP_035565
swissprot - O09164
swissprot - Q542X9
Ensembl - ENSMUSG00000072941
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sod3aENSDARG00000070168Danio rerio
 sod3bENSDARG00000079183Danio rerio
 SOD3ENSGALG00000018557Gallus gallus
 SOD3ENSG00000109610Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sod1 / P08228 / Superoxide dismutase [Cu-Zn] / P00441* / superoxide dismutase 1*ENSMUSG0000002298222
Ccs / Q9WU84 / Copper chaperone for superoxide dismutase / O14618*ENSMUSG0000003410820


Protein motifs (from Interpro)
Interpro ID Name
 IPR001424  Superoxide dismutase, copper/zinc binding domain
 IPR018152  Superoxide dismutase, copper/zinc, binding site
 IPR024134  Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
 IPR036423  Superoxide dismutase-like, copper/zinc binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0006801 superoxide metabolic process IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004784 superoxide dismutase activity IDA
 molecular_functionGO:0005507 copper ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Detoxification of Reactive Oxygen Species


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crhtm1Maj/Crhtm1Maj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Crhtm1Maj/Crhtm1Maj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Crhtm1Maj/Crhtm1Maj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh
Genetic Background: B6.129-Gpx1tm1Ysh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000072941 Sod3 / O09164 / superoxide dismutase 3, extracellular / P08294* / superoxide dismutase 3*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr