ENSG00000110721


Homo sapiens

Features
Gene ID: ENSG00000110721
  
Biological name :CHKA
  
Synonyms : CHKA / choline kinase alpha / P35790
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.2
Gene start: 68052859
Gene end: 68121444
  
Corresponding Affymetrix probe sets: 204233_s_at (Human Genome U133 Plus 2.0 Array)   204266_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435032
Ensembl peptide - ENSP00000265689
Ensembl peptide - ENSP00000348454
Ensembl peptide - ENSP00000432631
NCBI entrez gene - 1119     See in Manteia.
OMIM - 118491
RefSeq - XM_017017148
RefSeq - NM_001277
RefSeq - NM_212469
RefSeq - XM_017017147
RefSeq Peptide - NP_001268
RefSeq Peptide - NP_997634
swissprot - H0YD02
swissprot - P35790
swissprot - E9PM06
Ensembl - ENSG00000110721
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chkaENSDARG00000041078Danio rerio
 CHKAENSGALG00000036754Gallus gallus
 ChkaENSMUSG00000024843Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHKB / Q9Y259 / choline kinase betaENSG0000010028849
ETNK1 / Q9HBU6 / ethanolamine kinase 1ENSG0000013916326
ETNK2 / Q9NVF9 / ethanolamine kinase 2ENSG0000014384520
CHKB-CPT1B / CHKB-CPT1B readthrough (NMD candidate)ENSG000002544138


Protein motifs (from Interpro)
Interpro ID Name
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006580 ethanolamine metabolic process IEA
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006646 phosphatidylethanolamine biosynthetic process TAS
 biological_processGO:0006656 phosphatidylcholine biosynthetic process TAS
 biological_processGO:0006657 CDP-choline pathway IEA
 biological_processGO:0006869 lipid transport TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019695 choline metabolic process IEA
 biological_processGO:1904681 response to 3-methylcholanthrene IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004103 choline kinase activity TAS
 molecular_functionGO:0004104 cholinesterase activity IEA
 molecular_functionGO:0004305 ethanolamine kinase activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0033265 choline binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC
Synthesis of PE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110721 CHKA / P35790 / choline kinase alpha  / complex
 ENSG00000100288 CHKB / Q9Y259 / choline kinase beta  / complex






 

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