ENSMUSG00000024843


Mus musculus

Features
Gene ID: ENSMUSG00000024843
  
Biological name :Chka
  
Synonyms : Chka / Choline kinase alpha / O54804
  
Possible biological names infered from orthology : P35790
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 3851773
Gene end: 3894369
  
Corresponding Affymetrix probe sets: 10460221 (MoGene1.0st)   1442277_at (Mouse Genome 430 2.0 Array)   1450264_a_at (Mouse Genome 430 2.0 Array)   1453582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119919
Ensembl peptide - ENSMUSP00000116427
Ensembl peptide - ENSMUSP00000119493
Ensembl peptide - ENSMUSP00000025760
Ensembl peptide - ENSMUSP00000071933
Ensembl peptide - ENSMUSP00000115861
NCBI entrez gene - 12660     See in Manteia.
MGI - MGI:107760
RefSeq - XM_017318050
RefSeq - XM_006531649
RefSeq - XM_006531650
RefSeq - XM_006531651
RefSeq - XM_011248599
RefSeq - XM_011248600
RefSeq - XM_017318048
RefSeq - XM_017318049
RefSeq - NM_001271496
RefSeq - NM_013490
RefSeq - XM_006531646
RefSeq - XM_006531648
RefSeq Peptide - NP_038518
RefSeq Peptide - NP_001258425
swissprot - Q5J2U5
swissprot - F7AYX1
swissprot - O54804
swissprot - D6RG40
swissprot - F6S062
Ensembl - ENSMUSG00000024843
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chkaENSDARG00000041078Danio rerio
 CHKAENSGALG00000036754Gallus gallus
 CHKAENSG00000110721Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chkb / O55229 / Choline/ethanolamine kinase / Q9Y259* / CHKB-CPT1B* / choline kinase beta* / CHKB-CPT1B readthrough (NMD candidate)*ENSMUSG0000002261749
Etnk1 / Q9D4V0 / Ethanolamine kinase 1 / Q9HBU6*ENSMUSG0000003027525
Etnk2 / A7MCT6 / Ethanolamine kinase 2 / Q9NVF9*ENSMUSG0000007064424
AC137513.1 / CHKB* / Q9Y259* / CHKB-CPT1B* / choline kinase beta* / CHKB-CPT1B readthrough (NMD candidate)*ENSMUSG0000011646120


Protein motifs (from Interpro)
Interpro ID Name
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006580 ethanolamine metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006646 phosphatidylethanolamine biosynthetic process ISO
 biological_processGO:0006656 phosphatidylcholine biosynthetic process ISO
 biological_processGO:0006657 CDP-choline pathway IEA
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019695 choline metabolic process IEA
 biological_processGO:1904681 response to 3-methylcholanthrene IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004103 choline kinase activity ISO
 molecular_functionGO:0004104 cholinesterase activity IDA
 molecular_functionGO:0004305 ethanolamine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0033265 choline binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
Synthesis of PC
Synthesis of PE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcnq1ot1tm2Mjh/Kcnq1ot1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Kcnq1ot1tm2Mjh/Kcnq1ot1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024843 Chka / O54804 / Choline kinase alpha / P35790*  / complex
 ENSMUSG00000022617 Chkb / O55229 / Choline/ethanolamine kinase / Q9Y259* / CHKB-CPT1B* / choline kinase beta* / CHKB-CPT1B readthrough (NMD candidate)*  / complex






 

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contact: otassy@igbmc.fr