ENSG00000111641


Homo sapiens

Features
Gene ID: ENSG00000111641
  
Biological name :NOP2
  
Synonyms : NOP2 / NOP2 nucleolar protein / P46087
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 6556863
Gene end: 6568691
  
Corresponding Affymetrix probe sets: 214427_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484384
Ensembl peptide - ENSP00000445402
Ensembl peptide - ENSP00000479320
Ensembl peptide - ENSP00000313272
Ensembl peptide - ENSP00000371858
Ensembl peptide - ENSP00000382392
Ensembl peptide - ENSP00000439422
Ensembl peptide - ENSP00000440754
Ensembl peptide - ENSP00000441923
Ensembl peptide - ENSP00000442742
Ensembl peptide - ENSP00000442895
Ensembl peptide - ENSP00000443035
Ensembl peptide - ENSP00000443150
Ensembl peptide - ENSP00000443585
Ensembl peptide - ENSP00000444437
NCBI entrez gene - 4839     See in Manteia.
OMIM - 164031
RefSeq - XM_005253691
RefSeq - NM_001033714
RefSeq - NM_001258308
RefSeq - NM_001258309
RefSeq - NM_001258310
RefSeq - NM_006170
RefSeq Peptide - NP_001245238
RefSeq Peptide - NP_001245239
RefSeq Peptide - NP_006161
RefSeq Peptide - NP_001028886
RefSeq Peptide - NP_001245237
swissprot - F5H709
swissprot - F5H8G6
swissprot - F5GYR3
swissprot - F5H359
swissprot - F5H5X6
swissprot - P46087
swissprot - F5GWB7
Ensembl - ENSG00000111641
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nop2ENSDARG00000043304Danio rerio
 NOP2ENSGALG00000037807Gallus gallus
 Nop2ENSMUSG00000038279Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NSUN6 / Q8TEA1 / NOP2/Sun RNA methyltransferase family member 6ENSG0000024105813
NSUN3 / Q9H649 / NOP2/Sun RNA methyltransferase family member 3ENSG0000017869411
NSUN4 / Q96CB9 / NOP2/Sun RNA methyltransferase family member 4ENSG0000011748110


Protein motifs (from Interpro)
Interpro ID Name
 IPR001678  SAM-dependent methyltransferase RsmB/NOP2-type
 IPR011023  Nop2p
 IPR012586  P120R repeat
 IPR018314  Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site
 IPR023267  RNA (C5-cytosine) methyltransferase
 IPR023273  RNA (C5-cytosine) methyltransferase, NOP2
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR031341  Ribosomal RNA small subunit methyltransferase F, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000027 ribosomal large subunit assembly IMP
 biological_processGO:0000470 maturation of LSU-rRNA IBA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0070475 rRNA base methylation IBA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity IEA
 molecular_functionGO:0009383 rRNA (cytosine-C5-)-methyltransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
rRNA modification in the nucleus and cytosol
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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