ENSG00000117481


Homo sapiens

Features
Gene ID: ENSG00000117481
  
Biological name :NSUN4
  
Synonyms : NOP2/Sun RNA methyltransferase family member 4 / NSUN4 / Q96CB9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p33
Gene start: 46340177
Gene end: 46365152
  
Corresponding Affymetrix probe sets: 1559848_at (Human Genome U133 Plus 2.0 Array)   226351_at (Human Genome U133 Plus 2.0 Array)   230023_at (Human Genome U133 Plus 2.0 Array)   236247_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471937
Ensembl peptide - ENSP00000483680
Ensembl peptide - ENSP00000478949
Ensembl peptide - ENSP00000478740
Ensembl peptide - ENSP00000477553
Ensembl peptide - ENSP00000419740
Ensembl peptide - ENSP00000437758
NCBI entrez gene - 387338     See in Manteia.
OMIM - 615394
RefSeq - NM_001256127
RefSeq - NM_001256128
RefSeq - NM_199044
RefSeq Peptide - NP_950245
RefSeq Peptide - NP_001243056
RefSeq Peptide - NP_001243057
swissprot - Q96CB9
swissprot - A0A087WUV3
swissprot - A0A087WT36
swissprot - M0R1K5
swissprot - Q6ZRQ1
swissprot - A0A087X0V6
Ensembl - ENSG00000117481
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsun4ENSDARG00000021324Danio rerio
 NSUN4ENSGALG00000010360Gallus gallus
 Nsun4ENSMUSG00000028706Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NSUN3 / Q9H649 / NOP2/Sun RNA methyltransferase family member 3ENSG0000017869429
NOP2 / P46087 / NOP2 nucleolar proteinENSG0000011164122
NSUN6 / Q8TEA1 / NOP2/Sun RNA methyltransferase family member 6ENSG0000024105820


Protein motifs (from Interpro)
Interpro ID Name
 IPR001678  SAM-dependent methyltransferase RsmB/NOP2-type
 IPR023267  RNA (C5-cytosine) methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0031167 rRNA methylation TAS
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042256 mature ribosome assembly IEA
 biological_processGO:0070131 positive regulation of mitochondrial translation IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005762 mitochondrial large ribosomal subunit IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IDA
 molecular_functionGO:0009383 rRNA (cytosine-C5-)-methyltransferase activity EXP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019843 rRNA binding IEA
 molecular_functionGO:0070181 small ribosomal subunit rRNA binding IEA


Pathways (from Reactome)
Pathway description
rRNA modification in the mitochondrion


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122085 MTERF4 / Q7Z6M4 / mitochondrial transcription termination factor 4  / complex






 

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