ENSG00000114127


Homo sapiens

Features
Gene ID: ENSG00000114127
  
Biological name :XRN1
  
Synonyms : 5-3 exoribonuclease 1 / Q8IZH2 / XRN1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q23
Gene start: 142306607
Gene end: 142448062
  
Corresponding Affymetrix probe sets: 1555785_a_at (Human Genome U133 Plus 2.0 Array)   1570394_at (Human Genome U133 Plus 2.0 Array)   225814_at (Human Genome U133 Plus 2.0 Array)   233632_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420634
Ensembl peptide - ENSP00000419683
Ensembl peptide - ENSP00000420786
Ensembl peptide - ENSP00000264951
Ensembl peptide - ENSP00000376707
Ensembl peptide - ENSP00000418404
Ensembl peptide - ENSP00000419219
NCBI entrez gene - 54464     See in Manteia.
OMIM - 607994
RefSeq - XM_017006642
RefSeq - NM_001282857
RefSeq - NM_001282859
RefSeq - NM_019001
RefSeq - XM_011512919
RefSeq - XM_011512920
RefSeq - XM_011512922
RefSeq - XM_017006640
RefSeq - XM_017006641
RefSeq Peptide - NP_061874
RefSeq Peptide - NP_001269786
RefSeq Peptide - NP_001269788
swissprot - F8WDA0
swissprot - C9JCZ8
swissprot - Q8IZH2
swissprot - H7C583
swissprot - H7C5E4
Ensembl - ENSG00000114127
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xrn1ENSDARG00000091652Danio rerio
 XRN1ENSGALG00000002706Gallus gallus
 Xrn1ENSMUSG00000032410Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004859  Putative 5-3 exonuclease
 IPR016494  5"-3" exoribonuclease 1
 IPR027073  5"-3" exoribonuclease
 IPR029060  PIN-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IMP
 biological_processGO:0016075 rRNA catabolic process IMP
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IC
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0071028 nuclear mRNA surveillance IMP
 biological_processGO:0071044 histone mRNA catabolic process IMP
 biological_processGO:0071409 cellular response to cycloheximide IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic ISS
 biological_processGO:1905795 cellular response to puromycin IEA
 cellular_componentGO:0000932 P-body IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0002151 G-quadruplex RNA binding ISS
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0004534 5"-3" exoribonuclease activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008409 5"-3" exonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0051880 G-quadruplex DNA binding ISS
 molecular_functionGO:0070034 telomerase RNA binding IC


Pathways (from Reactome)
Pathway description
mRNA decay by 5 to 3 exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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