ENSG00000115942


Homo sapiens

Features
Gene ID: ENSG00000115942
  
Biological name :ORC2
  
Synonyms : ORC2 / origin recognition complex subunit 2 / Q13416
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q33.1
Gene start: 200908973
Gene end: 200963680
  
Corresponding Affymetrix probe sets: 204853_at (Human Genome U133 Plus 2.0 Array)   235423_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000234296
Ensembl peptide - ENSP00000396641
Ensembl peptide - ENSP00000386390
NCBI entrez gene - 4999     See in Manteia.
OMIM - 601182
RefSeq - XM_006712555
RefSeq - XM_011511253
RefSeq - XM_011511252
RefSeq - NM_006190
RefSeq Peptide - NP_006181
swissprot - Q13416
swissprot - C9JK08
swissprot - A0A024R411
swissprot - B8ZZ80
Ensembl - ENSG00000115942
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 orc2ENSDARG00000101465Danio rerio
 ORC2ENSGALG00000008234Gallus gallus
 Orc2ENSMUSG00000026037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007220  Origin recognition complex, subunit 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006260 DNA replication TAS
 biological_processGO:0006270 DNA replication initiation TAS
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0000808 origin recognition complex IDA
 cellular_componentGO:0000939 condensed chromosome inner kinetochore IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005664 nuclear origin of replication recognition complex IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0003688 DNA replication origin binding IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091651 ORC6 / Q9Y5N6 / origin recognition complex subunit 6  / reaction
 ENSG00000135336 ORC3 / Q9UBD5 / origin recognition complex subunit 3  / reaction / complex
 ENSG00000115947 ORC4 / O43929 / origin recognition complex subunit 4  / complex / reaction
 ENSG00000125885 MCM8 / Q9UJA3 / minichromosome maintenance 8 homologous recombination repair factor  / complex
 ENSG00000164815 ORC5 / O43913 / origin recognition complex subunit 5  / complex / reaction
 ENSG00000085840 ORC1 / Q13415 / origin recognition complex subunit 1  / reaction / complex






 

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