ENSG00000164815


Homo sapiens

Features
Gene ID: ENSG00000164815
  
Biological name :ORC5
  
Synonyms : O43913 / ORC5 / origin recognition complex subunit 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.2
Gene start: 104126341
Gene end: 104208047
  
Corresponding Affymetrix probe sets: 204957_at (Human Genome U133 Plus 2.0 Array)   211212_s_at (Human Genome U133 Plus 2.0 Array)   211213_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393208
Ensembl peptide - ENSP00000486840
Ensembl peptide - ENSP00000395747
Ensembl peptide - ENSP00000297431
Ensembl peptide - ENSP00000387465
NCBI entrez gene - 5001     See in Manteia.
OMIM - 602331
RefSeq - NM_002553
RefSeq - NM_181747
RefSeq Peptide - NP_002544
RefSeq Peptide - NP_859531
swissprot - O43913
swissprot - G3V0H0
swissprot - A4D0P7
Ensembl - ENSG00000164815
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 orc5ENSDARG00000021579Danio rerio
 ORC5ENSGALG00000008175Gallus gallus
 Orc5ENSMUSG00000029012Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR020796  Origin recognition complex, subunit 5
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle TAS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006270 DNA replication initiation TAS
 cellular_componentGO:0000784 nuclear chromosome, telomeric region HDA
 cellular_componentGO:0000808 origin recognition complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005664 nuclear origin of replication recognition complex NAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding TAS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003688 DNA replication origin binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135336 ORC3 / Q9UBD5 / origin recognition complex subunit 3  / complex / reaction
 ENSG00000115947 ORC4 / O43929 / origin recognition complex subunit 4  / reaction / complex
 ENSG00000091651 ORC6 / Q9Y5N6 / origin recognition complex subunit 6  / reaction
 ENSG00000115942 ORC2 / Q13416 / origin recognition complex subunit 2  / complex / reaction
 ENSG00000085840 ORC1 / Q13415 / origin recognition complex subunit 1  / reaction / complex






 

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