ENSG00000116120


Homo sapiens

Features
Gene ID: ENSG00000116120
  
Biological name :FARSB
  
Synonyms : FARSB / phenylalanyl-tRNA synthetase beta subunit / Q9NSD9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q36.1
Gene start: 222570536
Gene end: 222656337
  
Corresponding Affymetrix probe sets: 223035_s_at (Human Genome U133 Plus 2.0 Array)   223036_at (Human Genome U133 Plus 2.0 Array)   232063_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000281828
NCBI entrez gene - 10056     See in Manteia.
OMIM - 609690
RefSeq - XM_017003110
RefSeq - NM_005687
RefSeq - XM_006712169
RefSeq - XM_011510466
RefSeq Peptide - NP_005678
swissprot - Q9NSD9
Ensembl - ENSG00000116120
  
Related genetic diseases (OMIM): 618007 - ?Neurodevelopmental disorder with brain, liver, and lung abnormalities, 618007
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 farsbENSDARG00000016864Danio rerio
 FARSBENSGALG00000005236Gallus gallus
 FarsbENSMUSG00000026245Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC47 / Q8N1G4 / leucine rich repeat containing 47ENSG0000013076415


Protein motifs (from Interpro)
Interpro ID Name
 IPR004531  Phenylalanyl-tRNA synthetase, class IIc, beta subunit, archae/euk cytosolic
 IPR005146  B3/B4 tRNA-binding domain
 IPR005147  tRNA synthetase, B5-domain
 IPR009061  Putative DNA-binding domain superfamily
 IPR020825  Phenylalanyl-tRNA synthetase, B3/B4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation TAS
 biological_processGO:0006418 tRNA aminoacylation for protein translation TAS
 biological_processGO:0006432 phenylalanyl-tRNA aminoacylation IDA
 biological_processGO:0051290 protein heterotetramerization IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0009328 phenylalanine-tRNA ligase complex IDA
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004826 phenylalanine-tRNA ligase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Cytosolic tRNA aminoacylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116120 FARSB / Q9NSD9 / phenylalanyl-tRNA synthetase beta subunit  / complex
 ENSG00000179115 FARSA / Q9Y285 / phenylalanyl-tRNA synthetase alpha subunit  / complex






 

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