ENSG00000117228


Homo sapiens

Features
Gene ID: ENSG00000117228
  
Biological name :GBP1
  
Synonyms : GBP1 / guanylate binding protein 1 / P32455
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p22.2
Gene start: 89052319
Gene end: 89065360
  
Corresponding Affymetrix probe sets: 202269_x_at (Human Genome U133 Plus 2.0 Array)   202270_at (Human Genome U133 Plus 2.0 Array)   231577_s_at (Human Genome U133 Plus 2.0 Array)   231578_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359504
NCBI entrez gene - 2633     See in Manteia.
OMIM - 600411
RefSeq - NM_002053
RefSeq Peptide - NP_002044
swissprot - P32455
Ensembl - ENSG00000117228
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01068208.1ENSDARG00000112675Danio rerio
 CABZ01068209.1ENSDARG00000110616Danio rerio
 gbp1ENSDARG00000038668Danio rerio
 gbp2ENSDARG00000038669Danio rerio
 gbp4ENSDARG00000068857Danio rerio
 si:ch211-209n20.1ENSDARG00000099382Danio rerio
 si:dkeyp-30d6.2ENSDARG00000103564Danio rerio
 unm_sa911ENSDARG00000034063Danio rerio
 zmp:0000000527ENSDARG00000005627Danio rerio
 ENSGALG00000000720Gallus gallus
 GBPENSGALG00000026152Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GBP3 / Q9H0R5 / guanylate binding protein 3ENSG0000011722687
GBP2 / P32456 / guanylate binding protein 2ENSG0000016264576
GBP5 / Q96PP8 / guanylate binding protein 5ENSG0000015445167
GBP7 / Q8N8V2 / guanylate binding protein 7ENSG0000021351255
GBP4 / Q96PP9 / guanylate binding protein 4ENSG0000016265455
GBP6 / Q6ZN66 / guanylate binding protein family member 6ENSG0000018334753


Protein motifs (from Interpro)
Interpro ID Name
 IPR003191  Guanylate-binding protein/Atlastin, C-terminal
 IPR015894  Guanylate-binding protein, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030386  GB1/RHD3-type guanine nucleotide-binding (G) domain
 IPR036543  Guanylate-binding protein, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0050848 regulation of calcium-mediated signaling IMP
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1900041 negative regulation of interleukin-2 secretion IMP
 biological_processGO:1903076 regulation of protein localization to plasma membrane IGI
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019003 GDP binding IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019955 cytokine binding IPI
 molecular_functionGO:0030507 spectrin binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0051879 Hsp90 protein binding IPI


Pathways (from Reactome)
Pathway description
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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