ENSG00000154451


Homo sapiens

Features
Gene ID: ENSG00000154451
  
Biological name :GBP5
  
Synonyms : GBP5 / guanylate binding protein 5 / Q96PP8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p22.2
Gene start: 89258950
Gene end: 89272804
  
Corresponding Affymetrix probe sets: 229625_at (Human Genome U133 Plus 2.0 Array)   238581_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403010
Ensembl peptide - ENSP00000359488
NCBI entrez gene - 115362     See in Manteia.
OMIM - 611467
RefSeq - NM_001134486
RefSeq - NM_052942
RefSeq Peptide - NP_001127958
RefSeq Peptide - NP_443174
swissprot - Q96PP8
swissprot - E7ETN8
Ensembl - ENSG00000154451
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01068208.1ENSDARG00000112675Danio rerio
 CABZ01068209.1ENSDARG00000110616Danio rerio
 gbp1ENSDARG00000038668Danio rerio
 gbp2ENSDARG00000038669Danio rerio
 gbp4ENSDARG00000068857Danio rerio
 si:ch211-209n20.1ENSDARG00000099382Danio rerio
 si:dkeyp-30d6.2ENSDARG00000103564Danio rerio
 unm_sa911ENSDARG00000034063Danio rerio
 zmp:0000000527ENSDARG00000005627Danio rerio
 ENSGALG00000000720Gallus gallus
 GBPENSGALG00000026152Gallus gallus
 Gbp5ENSMUSG00000105504Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GBP3 / Q9H0R5 / guanylate binding protein 3ENSG0000011722668
GBP1 / P32455 / guanylate binding protein 1ENSG0000011722867
GBP2 / P32456 / guanylate binding protein 2ENSG0000016264564
GBP7 / Q8N8V2 / guanylate binding protein 7ENSG0000021351252
GBP6 / Q6ZN66 / guanylate binding protein family member 6ENSG0000018334751
GBP4 / Q96PP9 / guanylate binding protein 4ENSG0000016265451


Protein motifs (from Interpro)
Interpro ID Name
 IPR003191  Guanylate-binding protein/Atlastin, C-terminal
 IPR015894  Guanylate-binding protein, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030386  GB1/RHD3-type guanine nucleotide-binding (G) domain
 IPR036543  Guanylate-binding protein, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0050702 interleukin-1 beta secretion IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0072616 interleukin-18 secretion IEA
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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