ENSMUSG00000105504


Mus musculus

Features
Gene ID: ENSMUSG00000105504
  
Biological name :Gbp5
  
Synonyms : Gbp5 / Guanylate-binding protein 5 / Q8CFB4
  
Possible biological names infered from orthology : Q96PP8
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: H1
Gene start: 142493978
Gene end: 142522344
  
Corresponding Affymetrix probe sets: 10496539 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000087587
Ensembl peptide - ENSMUSP00000142938
Ensembl peptide - ENSMUSP00000143336
NCBI entrez gene - 229898     See in Manteia.
MGI - MGI:2429943
RefSeq - NM_153564
RefSeq Peptide - NP_705792
swissprot - Q8BMN7
swissprot - Q8CFB4
Ensembl - ENSMUSG00000105504
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01068208.1ENSDARG00000112675Danio rerio
 CABZ01068209.1ENSDARG00000110616Danio rerio
 gbp1ENSDARG00000038668Danio rerio
 gbp2ENSDARG00000038669Danio rerio
 gbp4ENSDARG00000068857Danio rerio
 si:ch211-209n20.1ENSDARG00000099382Danio rerio
 si:dkeyp-30d6.2ENSDARG00000103564Danio rerio
 unm_sa911ENSDARG00000034063Danio rerio
 zmp:0000000527ENSDARG00000005627Danio rerio
 ENSGALG00000000720Gallus gallus
 GBPENSGALG00000026152Gallus gallus
 GBP5ENSG00000154451Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gbp2 / Q9Z0E6 / Guanylate-binding protein 2 / P32456*ENSMUSG0000002827055
Gbp2b / GBP2* / P32456* / guanylate binding protein 2*ENSMUSG0000004026454
Gbp3 / Q61107 / Mus musculus guanylate binding protein 3 (Gbp3), transcript variant 4, mRNA. / GBP4* / GBP7* / Q96PP9* / Q8N8V2* / guanylate binding protein 4* / guanylate binding protein 7*ENSMUSG0000002826846
Gbp6 / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000010471345
Gbp7 / GBP4* / Q8N8V2* / Q96PP9* / guanylate binding protein 4* / guanylate binding protein 7*ENSMUSG0000004025345
Gm43302 / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000007936245
Gbp10 / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000010509644
Gbp9 / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000002929844
Gbp4 / Mus musculus guanylate binding protein 4 (Gbp4), transcript variant 6, mRNA. / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000007936342
Gbp11 / Mus musculus guanylate binding protein 11 (Gbp11), transcript variant 1, mRNA. / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000009202140
Gbp8 / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000003443838


Protein motifs (from Interpro)
Interpro ID Name
 IPR003191  Guanylate-binding protein/Atlastin, C-terminal
 IPR015894  Guanylate-binding protein, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030386  GB1/RHD3-type guanine nucleotide-binding (G) domain
 IPR036543  Guanylate-binding protein, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0050702 interleukin-1 beta secretion IMP
 biological_processGO:0051289 protein homotetramerization ISO
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0072616 interleukin-18 secretion IMP
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IMP
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0008636 decreased circulating interleukin-18 level "reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0008642 decreased circulating interleukin-1 beta level "reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0008685 decreased interleukin-18 secretion "reduction in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(CAG-DMPK*)1323Coop/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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