ENSMUSG00000028270


Mus musculus

Features
Gene ID: ENSMUSG00000028270
  
Biological name :Gbp2
  
Synonyms : Gbp2 / Guanylate-binding protein 2 / Q9Z0E6
  
Possible biological names infered from orthology : P32456
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: H1
Gene start: 142620602
Gene end: 142638008
  
Corresponding Affymetrix probe sets: 10496592 (MoGene1.0st)   1418240_at (Mouse Genome 430 2.0 Array)   1435906_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132435
Ensembl peptide - ENSMUSP00000129039
NCBI entrez gene - 14469     See in Manteia.
MGI - MGI:102772
RefSeq - NM_010260
RefSeq Peptide - NP_034390
swissprot - E9Q2N7
swissprot - Q9Z0E6
Ensembl - ENSMUSG00000028270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01068208.1ENSDARG00000112675Danio rerio
 CABZ01068209.1ENSDARG00000110616Danio rerio
 gbp1ENSDARG00000038668Danio rerio
 gbp2ENSDARG00000038669Danio rerio
 gbp4ENSDARG00000068857Danio rerio
 si:ch211-209n20.1ENSDARG00000099382Danio rerio
 si:dkeyp-30d6.2ENSDARG00000103564Danio rerio
 unm_sa911ENSDARG00000034063Danio rerio
 zmp:0000000527ENSDARG00000005627Danio rerio
 ENSGALG00000000720Gallus gallus
 GBPENSGALG00000026152Gallus gallus
 GBP2ENSG00000162645Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gbp2b / GBP2* / P32456* / guanylate binding protein 2*ENSMUSG0000004026476
Gbp5 / Q8CFB4 / Guanylate-binding protein 5 / Q96PP8*ENSMUSG0000010550455
Gbp3 / Q61107 / Mus musculus guanylate binding protein 3 (Gbp3), transcript variant 4, mRNA. / GBP4* / GBP7* / Q96PP9* / Q8N8V2* / guanylate binding protein 4* / guanylate binding protein 7*ENSMUSG0000002826853
Gbp7 / GBP4* / Q8N8V2* / Q96PP9* / guanylate binding protein 4* / guanylate binding protein 7*ENSMUSG0000004025352
Gm43302 / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000007936250
Gbp6 / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000010471350
Gbp9 / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000002929849
Gbp10 / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000010509649
Gbp4 / Mus musculus guanylate binding protein 4 (Gbp4), transcript variant 6, mRNA. / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000007936347
Gbp8 / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000003443844
Gbp11 / Mus musculus guanylate binding protein 11 (Gbp11), transcript variant 1, mRNA. / GBP6* / Q6ZN66* / guanylate binding protein family member 6*ENSMUSG0000009202142


Protein motifs (from Interpro)
Interpro ID Name
 IPR003191  Guanylate-binding protein/Atlastin, C-terminal
 IPR015894  Guanylate-binding protein, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030386  GB1/RHD3-type guanine nucleotide-binding (G) domain
 IPR036543  Guanylate-binding protein, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035458 cellular response to interferon-beta IDA
 biological_processGO:0042832 defense response to protozoan IDA
 biological_processGO:0044406 adhesion of symbiont to host IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0015629 actin cytoskeleton ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0020005 symbiont-containing vacuole membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ei24tm1Hzha/Ei24tm1Hzha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0010750 increased susceptibility to parasitic infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ei24tm1Hzha/Ei24tm1Hzha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr