ENSG00000120053


Homo sapiens

Features
Gene ID: ENSG00000120053
  
Biological name :GOT1
  
Synonyms : glutamic-oxaloacetic transaminase 1 / GOT1 / P17174
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.2
Gene start: 99396870
Gene end: 99430624
  
Corresponding Affymetrix probe sets: 208813_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359539
NCBI entrez gene - 2805     See in Manteia.
OMIM - 138180
RefSeq - NM_002079
RefSeq Peptide - NP_002070
swissprot - A0A140VK69
swissprot - P17174
Ensembl - ENSG00000120053
  
Related genetic diseases (OMIM): 614419 - Aspartate aminotransferase, serum level of, QTL1, 614419
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 got1ENSDARG00000039093Danio rerio
 GOT1ENSGALG00000007484Gallus gallus
 Got1ENSMUSG00000025190Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GOT2 / P00505 / glutamic-oxaloacetic transaminase 2ENSG0000012516646
GOT1L1 / Q8NHS2 / glutamic-oxaloacetic transaminase 1 like 1ENSG0000016915440


Protein motifs (from Interpro)
Interpro ID Name
 IPR000796  Aspartate/other aminotransferase
 IPR004838  Aminotransferases, class-I, pyridoxal-phosphate-binding site
 IPR004839  Aminotransferase, class I/classII
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006094 gluconeogenesis TAS
 biological_processGO:0006103 2-oxoglutarate metabolic process ISS
 biological_processGO:0006107 oxaloacetate metabolic process IEA
 biological_processGO:0006114 glycerol biosynthetic process ISS
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006531 aspartate metabolic process ISS
 biological_processGO:0006532 aspartate biosynthetic process IBA
 biological_processGO:0006533 aspartate catabolic process IDA
 biological_processGO:0006536 glutamate metabolic process ISS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process TAS
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0019550 glutamate catabolic process to aspartate IEA
 biological_processGO:0019551 glutamate catabolic process to 2-oxoglutarate IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEP
 biological_processGO:0043648 dicarboxylic acid metabolic process IEA
 biological_processGO:0051384 response to glucocorticoid IEP
 biological_processGO:0055089 fatty acid homeostasis IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity TAS
 molecular_functionGO:0004609 phosphatidylserine decarboxylase activity IEA
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0031406 carboxylic acid binding IEA
 molecular_functionGO:0047801 L-cysteine:2-oxoglutarate aminotransferase activity ISS


Pathways (from Reactome)
Pathway description
Methionine salvage pathway
Gluconeogenesis
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120053 GOT1 / P17174 / glutamic-oxaloacetic transaminase 1  / complex






 

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