ENSG00000125166


Homo sapiens

Features
Gene ID: ENSG00000125166
  
Biological name :GOT2
  
Synonyms : glutamic-oxaloacetic transaminase 2 / GOT2 / P00505
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q21
Gene start: 58707131
Gene end: 58734357
  
Corresponding Affymetrix probe sets: 200708_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394100
Ensembl peptide - ENSP00000245206
Ensembl peptide - ENSP00000456205
NCBI entrez gene - 2806     See in Manteia.
OMIM - 138150
RefSeq - NM_002080
RefSeq - NM_001286220
RefSeq Peptide - NP_001273149
RefSeq Peptide - NP_002071
swissprot - P00505
swissprot - H3BRE7
Ensembl - ENSG00000125166
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 got2aENSDARG00000041068Danio rerio
 got2bENSDARG00000005840Danio rerio
 GOT2ENSGALG00000002321Gallus gallus
 Got2ENSMUSG00000031672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GOT1 / P17174 / glutamic-oxaloacetic transaminase 1ENSG0000012005345
GOT1L1 / Q8NHS2 / glutamic-oxaloacetic transaminase 1 like 1ENSG0000016915426


Protein motifs (from Interpro)
Interpro ID Name
 IPR000796  Aspartate/other aminotransferase
 IPR004838  Aminotransferases, class-I, pyridoxal-phosphate-binding site
 IPR004839  Aminotransferase, class I/classII
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006094 gluconeogenesis TAS
 biological_processGO:0006103 2-oxoglutarate metabolic process ISS
 biological_processGO:0006107 oxaloacetate metabolic process IEA
 biological_processGO:0006520 cellular amino acid metabolic process IEA
 biological_processGO:0006531 aspartate metabolic process ISS
 biological_processGO:0006532 aspartate biosynthetic process IEA
 biological_processGO:0006533 aspartate catabolic process IDA
 biological_processGO:0006536 glutamate metabolic process ISS
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process TAS
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0015908 fatty acid transport IEP
 biological_processGO:0019470 4-hydroxyproline catabolic process TAS
 biological_processGO:0019550 glutamate catabolic process to aspartate IEA
 biological_processGO:0019551 glutamate catabolic process to 2-oxoglutarate IEA
 biological_processGO:0043648 dicarboxylic acid metabolic process IEA
 biological_processGO:0045471 response to ethanol IDA
 biological_processGO:0046487 glyoxylate metabolic process TAS
 biological_processGO:0097052 L-kynurenine metabolic process IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity EXP
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008483 transaminase activity IEA
 molecular_functionGO:0016212 kynurenine-oxoglutarate transaminase activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0031406 carboxylic acid binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047578 4-hydroxyglutamate transaminase activity TAS


Pathways (from Reactome)
Pathway description
Degradation of cysteine and homocysteine
Glyoxylate metabolism and glycine degradation
Gluconeogenesis
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125166 GOT2 / P00505 / glutamic-oxaloacetic transaminase 2  / complex






 

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