ENSG00000123146


Homo sapiens

Features
Gene ID: ENSG00000123146
  
Biological name :ADGRE5
  
Synonyms : ADGRE5 / adhesion G protein-coupled receptor E5 / P48960
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.12
Gene start: 14380501
Gene end: 14408725
  
Corresponding Affymetrix probe sets: 202910_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467478
Ensembl peptide - ENSP00000465800
Ensembl peptide - ENSP00000467351
Ensembl peptide - ENSP00000242786
Ensembl peptide - ENSP00000349918
Ensembl peptide - ENSP00000351413
NCBI entrez gene - 976     See in Manteia.
OMIM - 601211
RefSeq - XM_017027547
RefSeq - NM_001025160
RefSeq - NM_001784
RefSeq - NM_078481
RefSeq - XM_011528451
RefSeq Peptide - NP_001775
RefSeq Peptide - NP_510966
RefSeq Peptide - NP_001020331
swissprot - P48960
swissprot - K7EPE8
swissprot - K7EKV5
swissprot - K7EPP8
Ensembl - ENSG00000123146
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgre5b.2ENSDARG00000104083Danio rerio
 adgre5b.3ENSDARG00000112943Danio rerio
 adgre5b.3ENSDARG00000089904Danio rerio
 si:ch211-241f5.3ENSDARG00000097680Danio rerio
 Adgre5ENSMUSG00000002885Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADGRE2 / Q9UHX3 / adhesion G protein-coupled receptor E2ENSG0000012750760
ADGRE1 / Q14246 / adhesion G protein-coupled receptor E1ENSG0000017483728
ADGRL3 / Q9HAR2 / adhesion G protein-coupled receptor L3ENSG0000015047127
ADGRE3 / Q9BY15 / adhesion G protein-coupled receptor E3ENSG0000013135527
ADGRL1 / O94910 / adhesion G protein-coupled receptor L1ENSG0000007207127
ADGRL2 / O95490 / adhesion G protein-coupled receptor L2ENSG0000011711427
ADGRL4 / Q9HBW9 / adhesion G protein-coupled receptor L4ENSG0000016261821
ADGRD1 / Q6QNK2 / adhesion G protein-coupled receptor D1ENSG0000011145221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001881  EGF-like calcium-binding domain
 IPR003056  GPCR, family 2, CD97 antigen
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000196352 CD55 / P08174 / CD55 molecule (Cromer blood group)  / complex / reaction






 

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