ENSMUSG00000002885


Mus musculus

Features
Gene ID: ENSMUSG00000002885
  
Biological name :Adgre5
  
Synonyms : Adgre5 / adhesion G protein-coupled receptor E5
  
Possible biological names infered from orthology : P48960
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 83723251
Gene end: 83741326
  
Corresponding Affymetrix probe sets: 10580033 (MoGene1.0st)   1418394_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138393
Ensembl peptide - ENSMUSP00000075240
Ensembl peptide - ENSMUSP00000105427
Ensembl peptide - ENSMUSP00000128220
Ensembl peptide - ENSMUSP00000002964
NCBI entrez gene - 26364     See in Manteia.
MGI - MGI:1347095
RefSeq - XM_017312836
RefSeq - NM_001163029
RefSeq - NM_001163030
RefSeq - NM_001163031
RefSeq - NM_011925
RefSeq - XM_006531033
RefSeq - XM_006531035
RefSeq Peptide - NP_036055
RefSeq Peptide - NP_001156502
RefSeq Peptide - NP_001156503
RefSeq Peptide - NP_001156501
swissprot - S4R1V8
swissprot - A0A0D9SEG8
swissprot - E9QMJ5
swissprot - E9QJS7
swissprot - Q9DC42
Ensembl - ENSMUSG00000002885
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgre5b.2ENSDARG00000104083Danio rerio
 adgre5b.3ENSDARG00000112943Danio rerio
 adgre5b.3ENSDARG00000089904Danio rerio
 si:ch211-241f5.3ENSDARG00000097680Danio rerio
 ADGRE5ENSG00000123146Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgre1 / Q61549 / Mus musculus adhesion G protein-coupled receptor E1 (Adgre1), transcript variant 2, mRNA. / Q14246* / adhesion G protein-coupled receptor E1*ENSMUSG0000000473028
Adgrl3 / Q80TS3 / Adhesion G protein-coupled receptor L3 / Q9HAR2*ENSMUSG0000003760526
Adgrl2 / Q8JZZ7 / Adhesion G protein-coupled receptor L2 / O95490*ENSMUSG0000002818425
Adgrl1 / Q80TR1 / Adhesion G protein-coupled receptor L1 / O94910*ENSMUSG0000001303324
Adgrl4 / Q923X1 / Adhesion G protein-coupled receptor L4 / Q9HBW9*ENSMUSG0000003916723
Adgre4 / Q91ZE5 / Adhesion G protein-coupled receptor E4 ENSMUSG0000003291522
Adgrd1 / Q80T32 / Adhesion G-protein coupled receptor D1 / Q6QNK2*ENSMUSG0000004401721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001881  EGF-like calcium-binding domain
 IPR003056  GPCR, family 2, CD97 antigen
 IPR017981  GPCR, family 2-like
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syne1tm1Rexu/Syne1tm1Rexu,Syne2tm1Rexu/Syne2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Adgre5tm1.1Joha/Adgre5tm1.1Joha
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syne1tm1Rexu/Syne1tm1Rexu,Syne2tm1Rexu/Syne2+
Genetic Background: involves: 129 * C57BL/6

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Syne1tm1Rexu/Syne1tm1Rexu,Syne2tm1Rexu/Syne2+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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