ENSMUSG00000013033


Mus musculus

Features
Gene ID: ENSMUSG00000013033
  
Biological name :Adgrl1
  
Synonyms : Adgrl1 / Adhesion G protein-coupled receptor L1 / Q80TR1
  
Possible biological names infered from orthology : O94910
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C2
Gene start: 83900105
Gene end: 83941954
  
Corresponding Affymetrix probe sets: 10573234 (MoGene1.0st)   1428510_at (Mouse Genome 430 2.0 Array)   1452812_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118452
Ensembl peptide - ENSMUSP00000117720
Ensembl peptide - ENSMUSP00000118579
Ensembl peptide - ENSMUSP00000119100
Ensembl peptide - ENSMUSP00000048422
Ensembl peptide - ENSMUSP00000115295
Ensembl peptide - ENSMUSP00000116064
NCBI entrez gene - 330814     See in Manteia.
MGI - MGI:1929461
RefSeq - XM_011248415
RefSeq - XM_006531126
RefSeq - XM_006531127
RefSeq - XM_006531128
RefSeq - XM_011248410
RefSeq - XM_011248411
RefSeq - XM_011248412
RefSeq - XM_011248414
RefSeq - NM_181039
RefSeq - XM_006531120
RefSeq - XM_006531121
RefSeq - XM_006531122
RefSeq - XM_006531124
RefSeq - XM_006531125
RefSeq Peptide - NP_851382
swissprot - F6YP92
swissprot - H7BX15
swissprot - E9Q9Q9
swissprot - D6RI60
swissprot - Q80TR1
swissprot - E9Q3V9
Ensembl - ENSMUSG00000013033
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgrl1aENSDARG00000089292Danio rerio
 CABZ01096573.1ENSDARG00000111704Danio rerio
 ADGRL1ENSG00000072071Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgrl2 / Q8JZZ7 / Adhesion G protein-coupled receptor L2 / O95490*ENSMUSG0000002818464
Adgrl3 / Q80TS3 / Adhesion G protein-coupled receptor L3 / Q9HAR2*ENSMUSG0000003760555
Adgrl4 / Q923X1 / Adhesion G protein-coupled receptor L4 / Q9HBW9*ENSMUSG0000003916717
Adgre1 / Q61549 / Mus musculus adhesion G protein-coupled receptor E1 (Adgre1), transcript variant 2, mRNA. / Q14246* / adhesion G protein-coupled receptor E1*ENSMUSG0000000473014
Adgrd1 / Q80T32 / Adhesion G-protein coupled receptor D1 / Q6QNK2*ENSMUSG0000004401714
Adgre5 / adhesion G protein-coupled receptor E5 / P48960*ENSMUSG0000000288513
Adgre4 / Q91ZE5 / Adhesion G protein-coupled receptor E4 ENSMUSG0000003291512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR000922  D-galactoside/L-rhamnose binding SUEL lectin domain
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003112  Olfactomedin-like domain
 IPR003334  GPCR, family 2, latrophilin, C-terminal
 IPR003924  GPCR, family 2, latrophilin
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR031234  Latrophilin-1
 IPR032471  GAIN domain, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source ISS
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0090129 positive regulation of synapse maturation ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon ISS
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0042734 presynaptic membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection ISS
 cellular_componentGO:0045202 synapse ISS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016524 latrotoxin receptor activity ISS
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

Allelic Composition: Adgrl1tm1Sud/Adgrl1tm1Sud,Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0004494 abnormal synaptic glutamate release "aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrl1tm1Sud/Adgrl1tm1Sud,Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0004495 decreased synaptic glutamate release "reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd3etm1.1Lov/Cd3etm1.1Lov,Trdctm1Mal/Trdctm1Mal
Genetic Background: involves: C57BL/6

Allelic Composition: Adgrl1tm1Sud/Adgrl1tm1Sud,Nrxn1tm1Sud/Nrxn1tm1Sud
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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