ENSMUSG00000037605


Mus musculus

Features
Gene ID: ENSMUSG00000037605
  
Biological name :Adgrl3
  
Synonyms : Adgrl3 / Adhesion G protein-coupled receptor L3 / Q80TS3
  
Possible biological names infered from orthology : Q9HAR2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: D
Gene start: 81020138
Gene end: 81825133
  
Corresponding Affymetrix probe sets: 10522749 (MoGene1.0st)   1428523_at (Mouse Genome 430 2.0 Array)   1439313_at (Mouse Genome 430 2.0 Array)   1447551_x_at (Mouse Genome 430 2.0 Array)   1452819_at (Mouse Genome 430 2.0 Array)   1458742_at (Mouse Genome 430 2.0 Array)   1460440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112548
Ensembl peptide - ENSMUSP00000112731
Ensembl peptide - ENSMUSP00000118882
Ensembl peptide - ENSMUSP00000117211
Ensembl peptide - ENSMUSP00000114067
Ensembl peptide - ENSMUSP00000113950
Ensembl peptide - ENSMUSP00000113836
Ensembl peptide - ENSMUSP00000113694
Ensembl peptide - ENSMUSP00000113619
Ensembl peptide - ENSMUSP00000113600
Ensembl peptide - ENSMUSP00000113534
Ensembl peptide - ENSMUSP00000113482
Ensembl peptide - ENSMUSP00000113374
Ensembl peptide - ENSMUSP00000113249
Ensembl peptide - ENSMUSP00000113243
Ensembl peptide - ENSMUSP00000113208
Ensembl peptide - ENSMUSP00000112823
Ensembl peptide - ENSMUSP00000045342
Ensembl peptide - ENSMUSP00000072336
Ensembl peptide - ENSMUSP00000112388
Ensembl peptide - ENSMUSP00000112470
NCBI entrez gene - 319387     See in Manteia.
MGI - MGI:2441950
RefSeq - XM_017320922
RefSeq - XM_011249461
RefSeq - XM_011249462
RefSeq - XM_011249463
RefSeq - XM_011249464
RefSeq - XM_011249465
RefSeq - XM_011249466
RefSeq - XM_011249467
RefSeq - XM_011249468
RefSeq - XM_011249469
RefSeq - XM_011249470
RefSeq - XM_011249471
RefSeq - XM_011249472
RefSeq - XM_011249473
RefSeq - XM_011249474
RefSeq - XM_011249475
RefSeq - XM_017320913
RefSeq - XM_017320914
RefSeq - XM_017320915
RefSeq - XM_017320916
RefSeq - XM_017320917
RefSeq - XM_017320918
RefSeq - XM_017320919
RefSeq - XM_017320920
RefSeq - XM_017320921
RefSeq - NM_198702
RefSeq - XM_011249453
RefSeq - XM_011249454
RefSeq - XM_011249456
RefSeq - XM_011249457
RefSeq - XM_011249458
RefSeq - XM_011249459
RefSeq - XM_011249460
RefSeq Peptide - NP_001334297
RefSeq Peptide - NP_001334298
RefSeq Peptide - NP_001334300
RefSeq Peptide - NP_941991
RefSeq Peptide - NP_001334296
swissprot - D3Z593
swissprot - D3Z4V0
swissprot - D3Z4S7
swissprot - D3Z3X6
swissprot - D3Z3G4
swissprot - D3YWR3
swissprot - D3YWB1
swissprot - D3YVT9
swissprot - D3YU23
swissprot - F6WMY5
swissprot - K3W4M8
swissprot - D3YTW7
swissprot - D6RFB0
swissprot - D3Z6J2
swissprot - Q80TS3
swissprot - D3Z6H9
swissprot - D3Z6H7
swissprot - D3Z634
swissprot - D3Z5M6
Ensembl - ENSMUSG00000037605
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADGRL3ENSDARG00000090624Danio rerio
 adgrl3.1ENSDARG00000061121Danio rerio
 ADGRL3ENSGALG00000011319Gallus gallus
 ADGRL3ENSG00000150471Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgrl2 / Q8JZZ7 / Adhesion G protein-coupled receptor L2 / O95490*ENSMUSG0000002818457
Adgrl1 / Q80TR1 / Adhesion G protein-coupled receptor L1 / O94910*ENSMUSG0000001303352
Adgrl4 / Q923X1 / Adhesion G protein-coupled receptor L4 / Q9HBW9*ENSMUSG0000003916716
Adgre1 / Q61549 / Mus musculus adhesion G protein-coupled receptor E1 (Adgre1), transcript variant 2, mRNA. / Q14246* / adhesion G protein-coupled receptor E1*ENSMUSG0000000473014
Adgre5 / adhesion G protein-coupled receptor E5 / P48960*ENSMUSG0000000288514
Adgrd1 / Q80T32 / Adhesion G-protein coupled receptor D1 / Q6QNK2*ENSMUSG0000004401713
Adgre4 / Q91ZE5 / Adhesion G protein-coupled receptor E4 ENSMUSG0000003291512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR000922  D-galactoside/L-rhamnose binding SUEL lectin domain
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003112  Olfactomedin-like domain
 IPR003334  GPCR, family 2, latrophilin, C-terminal
 IPR003924  GPCR, family 2, latrophilin
 IPR015630  Latrophilin-3
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR032471  GAIN domain, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007416 synapse assembly IMP
 biological_processGO:0031987 locomotion involved in locomotory behavior IMP
 biological_processGO:0042220 response to cocaine IMP
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Neurog3*S183A*S187A)Axbe/?,Krt19tm1(cre/ERT)Ggu/?
Genetic Background: B6.Cg-Gt(ROSA)26Sortm1(Neurog3*S183A*S187A)Axbe Krt19tm1(cre/ERT)Ggu

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Itgb1tm10.1Ref/Itgb1tm10.1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr