ENSMUSG00000004730


Mus musculus

Features
Gene ID: ENSMUSG00000004730
  
Biological name :Adgre1
  
Synonyms : Adgre1 / Mus musculus adhesion G protein-coupled receptor E1 (Adgre1), transcript variant 2, mRNA. / Q61549
  
Possible biological names infered from orthology : adhesion G protein-coupled receptor E1 / Q14246
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: D
Gene start: 57358686
Gene end: 57483529
  
Corresponding Affymetrix probe sets: 10446282 (MoGene1.0st)   1451161_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004850
Ensembl peptide - ENSMUSP00000083971
NCBI entrez gene - 13733     See in Manteia.
MGI - MGI:106912
RefSeq - XM_006523602
RefSeq - NM_001355722
RefSeq - NM_010130
RefSeq - XM_006523601
RefSeq Peptide - NP_001342651
RefSeq Peptide - NP_034260
swissprot - Q3U9R0
swissprot - Q61549
Ensembl - ENSMUSG00000004730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgre10ENSDARG00000075855Danio rerio
 adgre14ENSDARG00000056062Danio rerio
 adgre15ENSDARG00000096588Danio rerio
 adgre16ENSDARG00000096622Danio rerio
 adgre17ENSDARG00000095297Danio rerio
 adgre18ENSDARG00000096644Danio rerio
 adgre19ENSDARG00000096649Danio rerio
 adgre6ENSDARG00000095494Danio rerio
 adgre7ENSDARG00000041399Danio rerio
 adgre8ENSDARG00000079050Danio rerio
 adgre9ENSDARG00000096577Danio rerio
 ADGRE1ENSG00000174837Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgre4 / Q91ZE5 / Adhesion G protein-coupled receptor E4 ENSMUSG0000003291526
Adgre5 / adhesion G protein-coupled receptor E5 / P48960*ENSMUSG0000000288524
Adgrl3 / Q80TS3 / Adhesion G protein-coupled receptor L3 / Q9HAR2*ENSMUSG0000003760523
Adgrl1 / Q80TR1 / Adhesion G protein-coupled receptor L1 / O94910*ENSMUSG0000001303322
Adgrl2 / Q8JZZ7 / Adhesion G protein-coupled receptor L2 / O95490*ENSMUSG0000002818422
Adgrd1 / Q80T32 / Adhesion G-protein coupled receptor D1 / Q6QNK2*ENSMUSG0000004401720
Adgrl4 / Q923X1 / Adhesion G protein-coupled receptor L4 / Q9HBW9*ENSMUSG0000003916720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000203  GPS motif
 IPR000742  EGF-like domain
 IPR000832  GPCR, family 2, secretin-like
 IPR001740  GPCR family 2, EMR1-like receptor
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR026823  Complement Clr-like EGF domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

Allelic Composition: Adgre1m3Btlr/Adgre1m3Btlr
Genetic Background: C57BL/6J-Adgre1m3Btlr

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Npm1tm1Hft/Npm1+
Genetic Background: involves: 129

Allelic Composition: Adgre1m3Btlr/Adgre1m3Btlr
Genetic Background: C57BL/6J-Adgre1m3Btlr

Allelic Composition: Adgre1M4Btlr/Adgre1M4Btlr
Genetic Background: C57BL/6J-Adgre1M4Btlr

Allelic Composition: Adgre1M4Btlr/Adgre1+
Genetic Background: C57BL/6J-Adgre1M4Btlr

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0005000 immune tolerance "the failure to respond to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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