ENSG00000123983


Homo sapiens

Features
Gene ID: ENSG00000123983
  
Biological name :ACSL3
  
Synonyms : ACSL3 / acyl-CoA synthetase long chain family member 3 / O95573
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q36.1
Gene start: 222860934
Gene end: 222944639
  
Corresponding Affymetrix probe sets: 201660_at (Human Genome U133 Plus 2.0 Array)   201661_s_at (Human Genome U133 Plus 2.0 Array)   201662_s_at (Human Genome U133 Plus 2.0 Array)   242726_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000416913
Ensembl peptide - ENSP00000385157
Ensembl peptide - ENSP00000438342
Ensembl peptide - ENSP00000441643
Ensembl peptide - ENSP00000350012
Ensembl peptide - ENSP00000375918
NCBI entrez gene - 2181     See in Manteia.
OMIM - 602371
RefSeq - XM_017003584
RefSeq - NM_001354158
RefSeq - NM_001354159
RefSeq - NM_004457
RefSeq - NM_203372
RefSeq Peptide - NP_004448
RefSeq Peptide - NP_976251
RefSeq Peptide - NP_001341087
RefSeq Peptide - NP_001341088
swissprot - F5H062
swissprot - H7BYZ7
swissprot - C9JC11
swissprot - F5GWH2
swissprot - O95573
swissprot - A0A024R497
Ensembl - ENSG00000123983
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acsl3aENSDARG00000032079Danio rerio
 acsl3bENSDARG00000014674Danio rerio
 ACSL3ENSGALG00000005206Gallus gallus
 Acsl3ENSMUSG00000032883Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACSL4 / O60488 / acyl-CoA synthetase long chain family member 4ENSG0000006836665
ACSL5 / Q9ULC5 / acyl-CoA synthetase long chain family member 5ENSG0000019714232
ACSL1 / P33121 / acyl-CoA synthetase long chain family member 1ENSG0000015172631
ACSL6 / Q9UKU0 / acyl-CoA synthetase long chain family member 6ENSG0000016439830
AC026398.1ENSG0000028193828
ACSBG1 / Q96GR2 / acyl-CoA synthetase bubblegum family member 1ENSG0000010374020
ACSBG2 / Q5FVE4 / acyl-CoA synthetase bubblegum family member 2ENSG0000013037719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR020845  AMP-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0034379 very-low-density lipoprotein particle assembly IMP
 biological_processGO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS
 biological_processGO:0042998 positive regulation of Golgi to plasma membrane protein transport IMP
 biological_processGO:0044539 long-chain fatty acid import IDA
 biological_processGO:0051047 positive regulation of secretion IMP
 biological_processGO:2001247 positive regulation of phosphatidylcholine biosynthetic process IMP
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004467 long-chain fatty acid-CoA ligase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0102391 decanoate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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