ENSG00000151726


Homo sapiens

Features
Gene ID: ENSG00000151726
  
Biological name :ACSL1
  
Synonyms : ACSL1 / acyl-CoA synthetase long chain family member 1 / P33121
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q35.1
Gene start: 184755595
Gene end: 184826818
  
Corresponding Affymetrix probe sets: 201963_at (Human Genome U133 Plus 2.0 Array)   207275_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425640
Ensembl peptide - ENSP00000425098
Ensembl peptide - ENSP00000426150
Ensembl peptide - ENSP00000485264
Ensembl peptide - ENSP00000426491
Ensembl peptide - ENSP00000426244
Ensembl peptide - ENSP00000281455
Ensembl peptide - ENSP00000407165
Ensembl peptide - ENSP00000422607
Ensembl peptide - ENSP00000424935
Ensembl peptide - ENSP00000425006
NCBI entrez gene - 2180     See in Manteia.
OMIM - 152425
RefSeq - XM_017007889
RefSeq - NM_001286708
RefSeq - NM_001286710
RefSeq - NM_001286711
RefSeq - NM_001286712
RefSeq - NM_001995
RefSeq - XM_005262828
RefSeq - XM_005262829
RefSeq - XM_005262831
RefSeq - XM_011531742
RefSeq - XM_017007887
RefSeq - XM_017007888
RefSeq Peptide - NP_001273637
RefSeq Peptide - NP_001273640
RefSeq Peptide - NP_001273641
RefSeq Peptide - NP_001986
RefSeq Peptide - NP_001273639
swissprot - H0Y9Z9
swissprot - B7Z3Z9
swissprot - P33121
swissprot - E7EPM6
swissprot - D6RG07
swissprot - D6RER0
swissprot - H0Y9U7
Ensembl - ENSG00000151726
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acsl1aENSDARG00000030514Danio rerio
 acsl1bENSDARG00000003854Danio rerio
 ACSL1ENSGALG00000010628Gallus gallus
 Acsl1ENSMUSG00000018796Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACSL6 / Q9UKU0 / acyl-CoA synthetase long chain family member 6ENSG0000016439867
AC026398.1ENSG0000028193863
ACSL5 / Q9ULC5 / acyl-CoA synthetase long chain family member 5ENSG0000019714260
ACSL3 / O95573 / acyl-CoA synthetase long chain family member 3ENSG0000012398332
ACSL4 / O60488 / acyl-CoA synthetase long chain family member 4ENSG0000006836630
ACSBG1 / Q96GR2 / acyl-CoA synthetase bubblegum family member 1ENSG0000010374024
ACSBG2 / Q5FVE4 / acyl-CoA synthetase bubblegum family member 2ENSG0000013037722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR020459  AMP-binding
 IPR020845  AMP-binding, conserved site
 IPR025110  AMP-binding enzyme, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process IDA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0015908 fatty acid transport IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0033211 adiponectin-activated signaling pathway IEA
 biological_processGO:0034201 response to oleic acid IEA
 biological_processGO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS
 biological_processGO:0036109 alpha-linolenic acid metabolic process TAS
 biological_processGO:0042178 xenobiotic catabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043651 linoleic acid metabolic process TAS
 biological_processGO:0044539 long-chain fatty acid import IDA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004467 long-chain fatty acid-CoA ligase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0102391 decanoate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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