ENSMUSG00000018796


Mus musculus

Features
Gene ID: ENSMUSG00000018796
  
Biological name :Acsl1
  
Synonyms : Acsl1 / Long-chain-fatty-acid--CoA ligase 1 / P41216
  
Possible biological names infered from orthology : acyl-CoA synthetase long chain family member 1 / P33121
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B1.1
Gene start: 46471037
Gene end: 46536051
  
Corresponding Affymetrix probe sets: 10571657 (MoGene1.0st)   1422526_at (Mouse Genome 430 2.0 Array)   1423883_at (Mouse Genome 430 2.0 Array)   1447355_at (Mouse Genome 430 2.0 Array)   1450643_s_at (Mouse Genome 430 2.0 Array)   1460316_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114473
Ensembl peptide - ENSMUSP00000106001
Ensembl peptide - ENSMUSP00000117546
Ensembl peptide - ENSMUSP00000147647
Ensembl peptide - ENSMUSP00000118845
Ensembl peptide - ENSMUSP00000034046
Ensembl peptide - ENSMUSP00000106000
NCBI entrez gene - 14081     See in Manteia.
MGI - MGI:102797
RefSeq - XM_017312563
RefSeq - NM_001302163
RefSeq - NM_007981
RefSeq - XM_006509262
RefSeq - XM_006509264
RefSeq - XM_006509265
RefSeq - XM_006509266
RefSeq Peptide - NP_001289092
RefSeq Peptide - NP_032007
swissprot - D3Z457
swissprot - D3Z041
swissprot - F6WNZ2
swissprot - D3YVF6
swissprot - P41216
swissprot - A0A1B0GRS8
Ensembl - ENSMUSG00000018796
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acsl1aENSDARG00000030514Danio rerio
 acsl1bENSDARG00000003854Danio rerio
 ACSL1ENSGALG00000010628Gallus gallus
 ACSL1ENSG00000151726Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acsl6 / Q91WC3 / Long-chain-fatty-acid--CoA ligase 6 / Q9UKU0* / AC026398.1* / acyl-CoA synthetase long chain family member 6*ENSMUSG0000002033365
Acsl5 / Q8JZR0 / Long-chain-fatty-acid--CoA ligase 5 / Q9ULC5* / acyl-CoA synthetase long chain family member 5*ENSMUSG0000002498159
Acsl3 / Q9CZW4 / Long-chain-fatty-acid--CoA ligase 3 / O95573* / acyl-CoA synthetase long chain family member 3*ENSMUSG0000003288331
Acsl4 / Q9QUJ7 / Long-chain-fatty-acid--CoA ligase 4 / O60488* / acyl-CoA synthetase long chain family member 4*ENSMUSG0000003127830
Acsbg1 / Q99PU5 / acyl-CoA synthetase bubblegum family member 1 / Q96GR2*ENSMUSG0000003228124
Acsbg2 / Q2XU92 / acyl-CoA synthetase bubblegum family member 2 / Q5FVE4*ENSMUSG0000002420723
1700061G19Rik / RIKEN cDNA 1700061G19 geneENSMUSG0000002420919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR020845  AMP-binding, conserved site
 IPR025110  AMP-binding enzyme, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process ISO
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0015908 fatty acid transport IEA
 biological_processGO:0033211 adiponectin-activated signaling pathway IMP
 biological_processGO:0034201 response to oleic acid IEA
 biological_processGO:0042178 xenobiotic catabolic process IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0044539 long-chain fatty acid import ISO
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IMP
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004467 long-chain fatty acid-CoA ligase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0102391 decanoate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acsl1tm1Rcol/Acsl1tm1Rcol,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0009288 increased epididymal fat pad weight 
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0011579 decreased lipoprotein lipase activity "reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

 MP:0014172 decreased fatty acid oxidation 
Show

Allelic Composition: Gnastm5Lsw/Gnastm5Lsw,Tg(Fabp4-cre)1Abel/0
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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