ENSMUSG00000032883


Mus musculus

Features
Gene ID: ENSMUSG00000032883
  
Biological name :Acsl3
  
Synonyms : Acsl3 / Long-chain-fatty-acid--CoA ligase 3 / Q9CZW4
  
Possible biological names infered from orthology : acyl-CoA synthetase long chain family member 3 / O95573
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C4
Gene start: 78657825
Gene end: 78707743
  
Corresponding Affymetrix probe sets: 10347748 (MoGene1.0st)   1428386_at (Mouse Genome 430 2.0 Array)   1428387_at (Mouse Genome 430 2.0 Array)   1452771_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117952
Ensembl peptide - ENSMUSP00000121695
Ensembl peptide - ENSMUSP00000045291
Ensembl peptide - ENSMUSP00000116576
NCBI entrez gene - 74205     See in Manteia.
MGI - MGI:1921455
RefSeq - NM_001033606
RefSeq - NM_001136222
RefSeq - NM_028817
RefSeq Peptide - NP_001129694
RefSeq Peptide - NP_083093
RefSeq Peptide - NP_001028778
swissprot - Q9CZW4
swissprot - D3Z4I4
swissprot - E9PUC2
Ensembl - ENSMUSG00000032883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acsl3aENSDARG00000032079Danio rerio
 acsl3bENSDARG00000014674Danio rerio
 ACSL3ENSGALG00000005206Gallus gallus
 ACSL3ENSG00000123983Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acsl4 / Q9QUJ7 / Long-chain-fatty-acid--CoA ligase 4 / O60488* / acyl-CoA synthetase long chain family member 4*ENSMUSG0000003127865
Acsl1 / P41216 / Long-chain-fatty-acid--CoA ligase 1 / P33121* / acyl-CoA synthetase long chain family member 1*ENSMUSG0000001879630
Acsl5 / Q8JZR0 / Long-chain-fatty-acid--CoA ligase 5 / Q9ULC5* / acyl-CoA synthetase long chain family member 5*ENSMUSG0000002498130
Acsl6 / Q91WC3 / Long-chain-fatty-acid--CoA ligase 6 / Q9UKU0* / AC026398.1* / acyl-CoA synthetase long chain family member 6*ENSMUSG0000002033330
Acsbg1 / Q99PU5 / acyl-CoA synthetase bubblegum family member 1 / Q96GR2*ENSMUSG0000003228120
Acsbg2 / Q2XU92 / acyl-CoA synthetase bubblegum family member 2 / Q5FVE4*ENSMUSG0000002420719
1700061G19Rik / RIKEN cDNA 1700061G19 geneENSMUSG0000002420916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR020845  AMP-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0034379 very-low-density lipoprotein particle assembly ISO
 biological_processGO:0042998 positive regulation of Golgi to plasma membrane protein transport ISO
 biological_processGO:0044539 long-chain fatty acid import ISO
 biological_processGO:0051047 positive regulation of secretion ISO
 biological_processGO:2001247 positive regulation of phosphatidylcholine biosynthetic process ISO
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005811 lipid droplet ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004467 long-chain fatty acid-CoA ligase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0102391 decanoate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(17)Thp/Map3k4C57BL/6J
Genetic Background: involves: AKR/J * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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