ENSMUSG00000031278


Mus musculus

Features
Gene ID: ENSMUSG00000031278
  
Biological name :Acsl4
  
Synonyms : Acsl4 / Long-chain-fatty-acid--CoA ligase 4 / Q9QUJ7
  
Possible biological names infered from orthology : acyl-CoA synthetase long chain family member 4 / O60488
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F2
Gene start: 142317993
Gene end: 142390535
  
Corresponding Affymetrix probe sets: 10607089 (MoGene1.0st)   1418911_s_at (Mouse Genome 430 2.0 Array)   1433531_at (Mouse Genome 430 2.0 Array)   1451828_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033634
Ensembl peptide - ENSMUSP00000108524
Ensembl peptide - ENSMUSP00000108525
Ensembl peptide - ENSMUSP00000108528
NCBI entrez gene - 50790     See in Manteia.
MGI - MGI:1354713
RefSeq - XM_011247843
RefSeq - NM_001033600
RefSeq - NM_019477
RefSeq - NM_207625
RefSeq - XM_011247842
RefSeq Peptide - NP_997508
RefSeq Peptide - NP_001028772
RefSeq Peptide - NP_062350
swissprot - Q91YN3
swissprot - Q9QUJ7
Ensembl - ENSMUSG00000031278
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acsl4aENSDARG00000004078Danio rerio
 ACSL4ENSGALG00000008088Gallus gallus
 ACSL4ENSG00000068366Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acsl3 / Q9CZW4 / Long-chain-fatty-acid--CoA ligase 3 / O95573* / acyl-CoA synthetase long chain family member 3*ENSMUSG0000003288365
Acsl5 / Q8JZR0 / Long-chain-fatty-acid--CoA ligase 5 / Q9ULC5* / acyl-CoA synthetase long chain family member 5*ENSMUSG0000002498130
Acsl1 / P41216 / Long-chain-fatty-acid--CoA ligase 1 / P33121* / acyl-CoA synthetase long chain family member 1*ENSMUSG0000001879629
Acsl6 / Q91WC3 / Long-chain-fatty-acid--CoA ligase 6 / Q9UKU0* / AC026398.1* / acyl-CoA synthetase long chain family member 6*ENSMUSG0000002033329
Acsbg2 / Q2XU92 / acyl-CoA synthetase bubblegum family member 2 / Q5FVE4*ENSMUSG0000002420720
Acsbg1 / Q99PU5 / acyl-CoA synthetase bubblegum family member 1 / Q96GR2*ENSMUSG0000003228119
1700061G19Rik / RIKEN cDNA 1700061G19 geneENSMUSG0000002420915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR020845  AMP-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process IEA
 biological_processGO:0006629 lipid metabolic process ISO
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008610 lipid biosynthetic process ISO
 biological_processGO:0015908 fatty acid transport IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process TAS
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030307 positive regulation of cell growth ISO
 biological_processGO:0032307 negative regulation of prostaglandin secretion ISO
 biological_processGO:0060136 embryonic process involved in female pregnancy IMP
 biological_processGO:0060996 dendritic spine development IEA
 biological_processGO:0070672 response to interleukin-15 IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004467 long-chain fatty acid-CoA ligase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0031957 very long-chain fatty acid-CoA ligase activity IEA
 molecular_functionGO:0047676 arachidonate-CoA ligase activity IEA
 molecular_functionGO:0102391 decanoate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001123 dilated uterus "stretched or enlarged female muscular organ of gestation" [J:50844]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002681 increased number of corpora lutea "greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Magel2tm1Stw/Magel2tm1Stw
Genetic Background: C57BL/6-Magel2tm1Stw/J

Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Acsl4tm1a(EUCOMM)Wtsi/Acsl4+
Genetic Background: B6Brd;B6Dnk;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004832 enlarged ovary "increased size of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009671 abnormal uterus physiology "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptentm1Rdp/Ptentm1Rdp,Tg(tetO-BRAF*V600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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