ENSMUSG00000024981


Mus musculus

Features
Gene ID: ENSMUSG00000024981
  
Biological name :Acsl5
  
Synonyms : Acsl5 / Long-chain-fatty-acid--CoA ligase 5 / Q8JZR0
  
Possible biological names infered from orthology : acyl-CoA synthetase long chain family member 5 / Q9ULC5
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 55251938
Gene end: 55297720
  
Corresponding Affymetrix probe sets: 10464045 (MoGene1.0st)   1428082_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046585
Ensembl peptide - ENSMUSP00000153474
Ensembl peptide - ENSMUSP00000153302
Ensembl peptide - ENSMUSP00000152972
Ensembl peptide - ENSMUSP00000152956
NCBI entrez gene - 433256     See in Manteia.
MGI - MGI:1919129
RefSeq - XM_006527178
RefSeq - NM_027976
RefSeq Peptide - NP_082252
swissprot - A0A286YD68
swissprot - A0A286YE29
swissprot - A0A286YCF3
swissprot - Q3UC67
swissprot - Q8JZR0
swissprot - A0A286YCG4
Ensembl - ENSMUSG00000024981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acsl5ENSDARG00000075931Danio rerio
 ACSL5ENSGALG00000008840Gallus gallus
 ACSL5ENSG00000197142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acsl1 / P41216 / Long-chain-fatty-acid--CoA ligase 1 / P33121* / acyl-CoA synthetase long chain family member 1*ENSMUSG0000001879660
Acsl6 / Q91WC3 / Long-chain-fatty-acid--CoA ligase 6 / Q9UKU0* / AC026398.1* / acyl-CoA synthetase long chain family member 6*ENSMUSG0000002033359
Acsl3 / Q9CZW4 / Long-chain-fatty-acid--CoA ligase 3 / O95573* / acyl-CoA synthetase long chain family member 3*ENSMUSG0000003288332
Acsl4 / Q9QUJ7 / Long-chain-fatty-acid--CoA ligase 4 / O60488* / acyl-CoA synthetase long chain family member 4*ENSMUSG0000003127831
Acsbg2 / Q2XU92 / acyl-CoA synthetase bubblegum family member 2 / Q5FVE4*ENSMUSG0000002420724
Acsbg1 / Q99PU5 / acyl-CoA synthetase bubblegum family member 1 / Q96GR2*ENSMUSG0000003228123
1700061G19Rik / RIKEN cDNA 1700061G19 geneENSMUSG0000002420919


Protein motifs (from Interpro)
Interpro ID Name
 IPR000873  AMP-dependent synthetase/ligase
 IPR020845  AMP-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001676 long-chain fatty acid metabolic process ISO
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:2001236 regulation of extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004467 long-chain fatty acid-CoA ligase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0102391 decanoate-CoA ligase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of very long-chain fatty acyl-CoAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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