ENSG00000124721


Homo sapiens

Features
Gene ID: ENSG00000124721
  
Biological name :DNAH8
  
Synonyms : DNAH8 / dynein axonemal heavy chain 8 / Q96JB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.2
Gene start: 38715341
Gene end: 39030529
  
Corresponding Affymetrix probe sets: 233052_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000333363
Ensembl peptide - ENSP00000362375
Ensembl peptide - ENSP00000377916
Ensembl peptide - ENSP00000415331
Ensembl peptide - ENSP00000352312
NCBI entrez gene - 1769     See in Manteia.
OMIM - 603337
RefSeq - XM_017010327
RefSeq - XM_011514318
RefSeq - XM_011514319
RefSeq - XM_011514320
RefSeq - XM_011514321
RefSeq - XM_017010325
RefSeq - XM_017010326
RefSeq - NM_001206927
RefSeq Peptide - NP_001193856
swissprot - H0Y7V4
swissprot - H3BLZ4
swissprot - A0A075B6F3
swissprot - Q8IU65
swissprot - Q96JB1
Ensembl - ENSG00000124721
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DNAH8ENSGALG00000010116Gallus gallus
 Dnah8ENSMUSG00000033826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DNAH17 / Q9UFH2 / dynein axonemal heavy chain 17ENSG0000018777528
DNAH2 / Q9P225 / dynein axonemal heavy chain 2ENSG0000018391428
DNAH11 / Q96DT5 / dynein axonemal heavy chain 11ENSG0000010587728
DNAH1 / Q9P2D7 / dynein axonemal heavy chain 1ENSG0000011484126
DNAH7 / Q8WXX0 / dynein axonemal heavy chain 7ENSG0000011899725
DNAH6 / Q9C0G6 / dynein axonemal heavy chain 6ENSG0000011542325
Q14204 / DYNC1H1 / dynein cytoplasmic 1 heavy chain 1ENSG0000019710222
DNAH14 / Q0VDD8 / dynein axonemal heavy chain 14ENSG000001858421


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR004273  Dynein heavy chain domain
 IPR011704  ATPase, dynein-related, AAA domain
 IPR013594  Dynein heavy chain, domain-1
 IPR013602  Dynein heavy chain, domain-2
 IPR024317  Dynein heavy chain, AAA module D4
 IPR024743  Dynein heavy chain, coiled coil stalk
 IPR026983  Dynein heavy chain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035699  Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1
 IPR035706  Dynein heavy chain, ATP-binding dynein motor region D5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003341 cilium movement IBA
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0036158 outer dynein arm assembly IBA
 biological_processGO:0060285 cilium-dependent cell motility NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005858 axonemal dynein complex NAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0030286 dynein complex IDA
 cellular_componentGO:0036157 outer dynein arm IBA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097228 sperm principal piece IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008569 ATP-dependent microtubule motor activity, minus-end-directed IBA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0045503 dynein light chain binding IBA
 molecular_functionGO:0045505 dynein intermediate chain binding IBA
 molecular_functionGO:0051959 dynein light intermediate chain binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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