ENSG00000131373


Homo sapiens

Features
Gene ID: ENSG00000131373
  
Biological name :HACL1
  
Synonyms : 2-hydroxyacyl-CoA lyase 1 / HACL1 / Q9UJ83
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p25.1
Gene start: 15560704
Gene end: 15601852
  
Corresponding Affymetrix probe sets: 223211_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000395278
Ensembl peptide - ENSP00000486684
Ensembl peptide - ENSP00000404883
Ensembl peptide - ENSP00000403656
Ensembl peptide - ENSP00000395352
Ensembl peptide - ENSP00000323811
Ensembl peptide - ENSP00000373289
Ensembl peptide - ENSP00000390699
Ensembl peptide - ENSP00000391393
Ensembl peptide - ENSP00000392796
NCBI entrez gene - 26061     See in Manteia.
OMIM - 604300
RefSeq - NM_012260
RefSeq - NM_001284413
RefSeq - NM_001284415
RefSeq - NM_001284416
RefSeq Peptide - NP_001271342
RefSeq Peptide - NP_001271345
RefSeq Peptide - NP_036392
RefSeq Peptide - NP_001271344
swissprot - Q9UJ83
swissprot - C9J306
swissprot - B3KPX4
swissprot - F8WCH9
swissprot - Q7Z773
swissprot - C9JJM7
Ensembl - ENSG00000131373
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hacl1ENSDARG00000020529Danio rerio
 HACL1ENSGALG00000011211Gallus gallus
 Hacl1ENSMUSG00000021884Mus musculus
 Hacl1ENSMUSG00000115022Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ILVBL / A1L0T0 / ilvB acetolactate synthase likeENSG0000010513526


Protein motifs (from Interpro)
Interpro ID Name
 IPR011766  Thiamine pyrophosphate enzyme, C-terminal TPP-binding
 IPR012000  Thiamine pyrophosphate enzyme, central domain
 IPR012001  Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
 IPR029035  DHS-like NAD/FAD-binding domain superfamily
 IPR029061  Thiamin diphosphate-binding fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001561 fatty acid alpha-oxidation IDA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0051259 protein complex oligomerization IDA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005782 peroxisomal matrix TAS
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016830 carbon-carbon lyase activity TAS
 molecular_functionGO:0030976 thiamine pyrophosphate binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048037 cofactor binding IDA


Pathways (from Reactome)
Pathway description
Alpha-oxidation of phytanate
Peroxisomal protein import


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131373 HACL1 / Q9UJ83 / 2-hydroxyacyl-CoA lyase 1  / complex






 

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