ENSG00000133083


Homo sapiens

Features
Gene ID: ENSG00000133083
  
Biological name :DCLK1
  
Synonyms : DCLK1 / doublecortin like kinase 1 / O15075
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q13.3
Gene start: 35768652
Gene end: 36131306
  
Corresponding Affymetrix probe sets: 205399_at (Human Genome U133 Plus 2.0 Array)   215303_at (Human Genome U133 Plus 2.0 Array)   229800_at (Human Genome U133 Plus 2.0 Array)   230962_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000369222
Ensembl peptide - ENSP00000255448
Ensembl peptide - ENSP00000353846
Ensembl peptide - ENSP00000369223
Ensembl peptide - ENSP00000484452
NCBI entrez gene - 9201     See in Manteia.
OMIM - 604742
RefSeq - XM_017020848
RefSeq - NM_001195415
RefSeq - NM_001195416
RefSeq - NM_001330071
RefSeq - NM_001330072
RefSeq - NM_004734
RefSeq - XM_005266592
RefSeq - XM_006719893
RefSeq - XM_017020847
RefSeq Peptide - NP_001182344
RefSeq Peptide - NP_001317000
RefSeq Peptide - NP_001317001
RefSeq Peptide - NP_004725
RefSeq Peptide - NP_001182345
swissprot - O15075
swissprot - Q5VZY9
Ensembl - ENSG00000133083
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dclk1aENSDARG00000018856Danio rerio
 dclk1bENSDARG00000104664Danio rerio
 DCLK1ENSGALG00000041263Gallus gallus
 Dclk1ENSMUSG00000027797Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DCLK2 / Q8N568 / doublecortin like kinase 2ENSG0000017039068
DCX / O43602 / doublecortinENSG0000007727935
DCLK3 / Q9C098 / doublecortin like kinase 3ENSG0000016367328
STK33 / Q9BYT3 / serine/threonine kinase 33ENSG0000013041318
PHKG1 / Q16816 / phosphorylase kinase catalytic subunit gamma 1ENSG0000016477616
PHKG2 / P15735 / phosphorylase kinase catalytic subunit gamma 2ENSG0000015687316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003533  Doublecortin domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017302  Neuronal migration protein doublecortin, chordata
 IPR017441  Protein kinase, ATP binding site
 IPR036572  Doublecortin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0009615 response to virus IEP
 biological_processGO:0016197 endosomal transport NAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:1900181 negative regulation of protein localization to nucleus IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0014069 postsynaptic density IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr