ENSMUSG00000027797


Mus musculus

Features
Gene ID: ENSMUSG00000027797
  
Biological name :Dclk1
  
Synonyms : Dclk1 / Mus musculus doublecortin-like kinase 1 (Dclk1), transcript variant 12, mRNA. / Q9JLM8
  
Possible biological names infered from orthology : doublecortin like kinase 1 / O15075
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: C
Gene start: 55242364
Gene end: 55539068
  
Corresponding Affymetrix probe sets: 10492136 (MoGene1.0st)   1423125_at (Mouse Genome 430 2.0 Array)   1424270_at (Mouse Genome 430 2.0 Array)   1424271_at (Mouse Genome 430 2.0 Array)   1435940_at (Mouse Genome 430 2.0 Array)   1436659_at (Mouse Genome 430 2.0 Array)   1446190_at (Mouse Genome 430 2.0 Array)   1450863_a_at (Mouse Genome 430 2.0 Array)   1451289_at (Mouse Genome 430 2.0 Array)   1451917_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142840
Ensembl peptide - ENSMUSP00000142698
Ensembl peptide - ENSMUSP00000143016
Ensembl peptide - ENSMUSP00000143672
Ensembl peptide - ENSMUSP00000143659
Ensembl peptide - ENSMUSP00000143563
Ensembl peptide - ENSMUSP00000143507
Ensembl peptide - ENSMUSP00000050034
Ensembl peptide - ENSMUSP00000070292
Ensembl peptide - ENSMUSP00000129334
Ensembl peptide - ENSMUSP00000142637
NCBI entrez gene - 13175     See in Manteia.
MGI - MGI:1330861
RefSeq - XM_017319448
RefSeq - NM_001111051
RefSeq - NM_001111052
RefSeq - NM_001111053
RefSeq - NM_001195538
RefSeq - NM_001195539
RefSeq - NM_001195540
RefSeq - NM_001357468
RefSeq - NM_001357475
RefSeq - NM_001357476
RefSeq - NM_019978
RefSeq - XM_006500978
RefSeq - XM_006500979
RefSeq - XM_006500981
RefSeq - XM_006500982
RefSeq - XM_006500983
RefSeq - XM_011240007
RefSeq - XM_017319447
RefSeq Peptide - NP_001104521
RefSeq Peptide - NP_001104523
RefSeq Peptide - NP_001182467
RefSeq Peptide - NP_001182468
RefSeq Peptide - NP_001182469
RefSeq Peptide - NP_001344397
RefSeq Peptide - NP_001344404
RefSeq Peptide - NP_001344405
RefSeq Peptide - NP_064362
RefSeq Peptide - NP_001104522
swissprot - Q1EDH1
swissprot - Q80VB6
swissprot - Q8CCN4
swissprot - Q9JLM8
swissprot - A0A0G2JE54
swissprot - A8IP62
swissprot - A0A0G2JGR9
swissprot - A0A0G2JGQ6
swissprot - A0A0G2JGH1
swissprot - H7BX36
swissprot - A0A0G2JEN4
Ensembl - ENSMUSG00000027797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dclk1aENSDARG00000018856Danio rerio
 dclk1bENSDARG00000104664Danio rerio
 DCLK1ENSGALG00000041263Gallus gallus
 DCLK1ENSG00000133083Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dclk2 / Q6PGN3 / Serine/threonine-protein kinase DCLK2 / Q8N568* / doublecortin like kinase 2*ENSMUSG0000002807865
Dcx / O88809 / Neuronal migration protein doublecortin / O43602* / doublecortin*ENSMUSG0000003128534
Dclk3 / Q8BWQ5 / Serine/threonine-protein kinase DCLK3 / Q9C098* / doublecortin like kinase 3*ENSMUSG0000003250030
Stk33 / Q924X7 / Serine/threonine-protein kinase 33 / Q9BYT3* / serine/threonine kinase 33*ENSMUSG0000003102718
Phkg1 / P07934 / Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform / Q16816* / phosphorylase kinase catalytic subunit gamma 1*ENSMUSG0000002553716
Phkg2 / Q9DB30 / Phosphorylase b kinase gamma catalytic chain, liver/testis isoform / P15735* / phosphorylase kinase catalytic subunit gamma 2*ENSMUSG0000003081515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003533  Doublecortin domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017302  Neuronal migration protein doublecortin, chordata
 IPR017441  Protein kinase, ATP binding site
 IPR036572  Doublecortin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007420 brain development IGI
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0048675 axon extension IGI
 biological_processGO:0048813 dendrite morphogenesis IGI
 biological_processGO:1900181 negative regulation of protein localization to nucleus IDA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0014069 postsynaptic density IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dcxtm1Caw/Dcx+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000801 abnormal temporal lobe morphology "malformation or absence of the lower lateral part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Scn11atm1Dgen/Scn11a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

Allelic Composition: Dclk1tm1Caw/Dclk1+,Dcxtm1Caw/Dcx+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mtmr1tm1Dgen/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Scn11atm1Dgen/Scn11a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dclk1tm1Caw/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1Caw/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhej1tm1.1Ics/Nhej1tm1.1Ics,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0006300 abnormal entorhinal cortex morphology "any structural anomaly of the structure in the anterior parahippocampus that lies forward of the parahippocampal cortex and immediately medial to the perirhinal cortex, bounded superiorly by the hippocampus and inferiorly by the collateral sulcus" [brs:Beverly Richards-Smith_IMSR Curator]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0008011 intestinal polyps "abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Dclk1tm1.1(cre/ERT2)Seno/Dclk1tm1.1(cre/ERT2)Seno
Genetic Background: involves: C57BL/6

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0008129 absent brain internal capsule "absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0008221 abnormal hippocampal commissure morphology "any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0008223 absent hippocampal commissure "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcx+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008227 absent anterior commissure "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1+,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Dclk1tm1.1Jgg/Dclk1tm1.1Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dclk1tm1Caw/Dclk1tm1Caw,Dcxtm1Caw/Y
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr