Manteia - Molecule gene

ENSMUSG00000031285

Mus musculus

Features

Gene ID:	ENSMUSG00000031285

Biological name :	Dcx

Synonyms :	Dcx / Neuronal migration protein doublecortin / O88809

Possible biological names infered from orthology :	doublecortin / O43602

Species:	Mus musculus

Chr. number:	X
Strand:	-1
Band:	F2
Gene start:	143855842
Gene end:	143933311

Corresponding Affymetrix probe sets:	10607156 (MoGene1.0st) 1418139_at (Mouse Genome 430 2.0 Array) 1418140_at (Mouse Genome 430 2.0 Array) 1418141_at (Mouse Genome 430 2.0 Array) 1448974_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000033642 Ensembl peptide - ENSMUSP00000084570 Ensembl peptide - ENSMUSP00000108472 Ensembl peptide - ENSMUSP00000108477 NCBI entrez gene - 13193 See in Manteia. MGI - MGI:1277171 RefSeq - XM_006528698 RefSeq - NM_001110222 RefSeq - NM_001110223 RefSeq - NM_001110224 RefSeq - NM_010025 RefSeq Peptide - NP_001103694 RefSeq Peptide - NP_034155 RefSeq Peptide - NP_001103692 RefSeq Peptide - NP_001103693 swissprot - O88809 swissprot - Q6PGI2 swissprot - Q9CXL6 Ensembl - ENSMUSG00000031285

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
DCX	ENSGALG00000007993	Gallus gallus
DCX	ENSG00000077279	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Dclk1 / Q9JLM8 / Mus musculus doublecortin-like kinase 1 (Dclk1), transcript variant 12, mRNA. / O15075* / doublecortin like kinase 1*	ENSMUSG00000027797	70
Dclk2 / Q6PGN3 / Serine/threonine-protein kinase DCLK2 / Q8N568* / doublecortin like kinase 2*	ENSMUSG00000028078	68
Dclk3 / Q8BWQ5 / Serine/threonine-protein kinase DCLK3 / Q9C098* / doublecortin like kinase 3*	ENSMUSG00000032500	16
Stk33 / Q924X7 / Serine/threonine-protein kinase 33 / Q9BYT3* / serine/threonine kinase 33*	ENSMUSG00000031027	7
Phkg2 / Q9DB30 / Phosphorylase b kinase gamma catalytic chain, liver/testis isoform / P15735* / phosphorylase kinase catalytic subunit gamma 2*	ENSMUSG00000030815	3
Phkg1 / P07934 / Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform / Q16816* / phosphorylase kinase catalytic subunit gamma 1*	ENSMUSG00000025537	2

Protein motifs (from Interpro)

Interpro ID	Name
IPR003533	Doublecortin domain
IPR017302	Neuronal migration protein doublecortin, chordata
IPR036572	Doublecortin domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001764	neuron migration	ISO
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0007420	brain development	IGI
biological_process	GO:0021766	hippocampus development	IMP
biological_process	GO:0021819	layer formation in cerebral cortex	IMP
biological_process	GO:0021860	pyramidal neuron development	IGI
biological_process	GO:0021952	central nervous system projection neuron axonogenesis	IGI
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
biological_process	GO:0048675	axon extension	IGI
biological_process	GO:0048813	dendrite morphogenesis	IGI
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0005874	microtubule	IEA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043005	neuron projection	ISS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008017	microtubule binding	ISO
molecular_function	GO:0019901	protein kinase binding	ISO

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000781	reduced size of corpus callosum	"smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000790	abnormal stratification in cerebral cortex	"abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000801	abnormal temporal lobe morphology	"malformation or absence of the lower lateral part of the cerebral hemisphere" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Cebpa^tm1Btp/Cebpa^tm1Btp Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dcx^tm1Caw/Dcx⁺ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0000813	abnormal hippocampal laminar structure	"malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000832	abnormal thalamus morphology	"malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000852	small cerebellum	"reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0000857	abnormal cerebellar foliation	"malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]	Show Allelic Composition: Scn11a^tm1Dgen/Scn11a⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000947	convulsive seizures	"seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Cebpa^tm1Btp/Cebpa^tm1Btp Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001462	abnormal avoidance learning behavior	"defects in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Cebpa^tm1Btp/Cebpa^tm1Btp Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dcx^tm1Caw/Dcx⁺ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Cx3cr1^tm1Zm/Cx3cr1⁺ Genetic Background: B6.129-Apoe^tm1Unc Cx3cr1^tm1Zm
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Cebpa^tm1Btp/Cebpa^tm1Btp Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001923	reduced female fertility	"reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J Allelic Composition: Dclk1^tm1Caw/Dclk1⁺,Dcx^tm1Caw/Dcx⁺ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0002082	postnatal lethality	"premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Mtmr1^tm1Dgen/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cebpa^tm1Btp/Cebpa^tm1Btp Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Scn11a^tm1Dgen/Scn11a⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dclk1^tm1Caw/Dclk1⁺,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0002196	acallosal	"absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1.1Jgg/Dclk1⁺,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1Caw/Dclk1⁺,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0002199	abnormal brain commissure morphology	"absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1⁺,Dcx^tm1Caw/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
MP:0002761	abnormal hippocampal mossy fiber morphology	"absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]	Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0002882	abnormal neuron	"anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1⁺,Dcx^tm1Caw/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
MP:0002945	abnormal inhibitory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0003240	loss of hippocampal neurons	"loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]	Show Allelic Composition: Braf^tm1.1Brd/Braf⁺,Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn,Tg(Vil1-cre)997Gum/0 Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * SJL
MP:0003997	tonic-clonic seizures	"increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0004077	abnormal striatum morphology	"malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0004101	abnormal brain interneuron morphology	"malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * CD-1 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0004279	abnormal rostral migratory stream morphology	"any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nog^tm1Amc/Nog⁺ Genetic Background: involves: 129S1/Sv * CD-1
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cebpa^tm1Btp/Cebpa^tm1Btp Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005277	abnormal brainstem morphology	"anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0006254	thin cerebral cortex	"decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0006300	abnormal entorhinal cortex morphology	"any structural anomaly of the structure in the anterior parahippocampus that lies forward of the parahippocampal cortex and immediately medial to the perirhinal cortex, bounded superiorly by the hippocampus and inferiorly by the collateral sulcus" [brs:Beverly Richards-Smith_IMSR Curator]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0008128	abnormal brain internal capsule morphology	"any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0008129	absent brain internal capsule	"absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0008221	abnormal hippocampal commissure morphology	"any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0008223	absent hippocampal commissure	"absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
MP:0008225	abnormal anterior commissure morphology	"any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0008226	decreased anterior commissure size	"reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1⁺,Dcx^tm1Caw/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
MP:0008227	absent anterior commissure	"absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
MP:0008262	abnormal hippocampus region morphology	"any structural anomaly of a part or parts of the hippocampus that have a particular function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0008263	abnormal hippocampus CA1 region morphology		Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0008267	abnormal hippocampus CA3 region morphology		Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0008284	abnormal hippocampus pyramidal cell layer		Show Allelic Composition: Cebpa^tm1Btp/Cebpa^tm1Btp Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dcx^tm1Caw/Dcx⁺ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0008285	abnormal hippocampus granule cell layer		Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclk1^tm1Caw/Dclk1⁺,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
MP:0009940	abnormal hippocampus pyramidal cell morphology	"any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Dcx^tm1Caw/Dcx⁺ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * Black Swiss
MP:0011085	complete postnatal lethality	"premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 Allelic Composition: Dclk1^tm1.1Jgg/Dclk1^tm1.1Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cebpa^tm1Btp/Cebpa^tm1Btp Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Dclk1^tm1Caw/Dclk1^tm1Caw,Dcx^tm1Caw/Y Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Dcx^tm1Caw Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg,Dcx^tm1Caw/Y Genetic Background: involves: 129/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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