Manteia

ENSMUSG00000030815

Mus musculus

Features

Gene ID:	ENSMUSG00000030815

Biological name :	Phkg2

Synonyms :	Phkg2 / Phosphorylase b kinase gamma catalytic chain, liver/testis isoform / Q9DB30

Possible biological names infered from orthology :	P15735 / phosphorylase kinase catalytic subunit gamma 2

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	F3
Gene start:	127573340
Gene end:	127583307

Corresponding Affymetrix probe sets:	10557705 (MoGene1.0st) 1428511_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000145834 Ensembl peptide - ENSMUSP00000113533 Ensembl peptide - ENSMUSP00000145927 Ensembl peptide - ENSMUSP00000115593 Ensembl peptide - ENSMUSP00000116860 Ensembl peptide - ENSMUSP00000033086 NCBI entrez gene - 68961 See in Manteia. MGI - MGI:1916211 RefSeq - XM_017312279 RefSeq - XM_006508168 RefSeq - XM_006508169 RefSeq - XM_006508170 RefSeq - XM_006508171 RefSeq - XM_006508172 RefSeq - XM_011241891 RefSeq - NM_026888 RefSeq - XM_006508167 RefSeq Peptide - NP_081164 swissprot - D6RG71 swissprot - A0A0U1RPC7 swissprot - A0A0U1RP54 swissprot - D6RGU6 swissprot - Q9DB30 Ensembl - ENSMUSG00000030815

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Phkg1 / P07934 / Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform / Q16816* / phosphorylase kinase catalytic subunit gamma 1*	ENSMUSG00000025537	59
Dclk2 / Q6PGN3 / Serine/threonine-protein kinase DCLK2 / Q8N568* / doublecortin like kinase 2*	ENSMUSG00000028078	30
Dclk1 / Q9JLM8 / Mus musculus doublecortin-like kinase 1 (Dclk1), transcript variant 12, mRNA. / O15075* / doublecortin like kinase 1*	ENSMUSG00000027797	28
Dclk3 / Q8BWQ5 / Serine/threonine-protein kinase DCLK3 / Q9C098* / doublecortin like kinase 3*	ENSMUSG00000032500	27
Stk33 / Q924X7 / Serine/threonine-protein kinase 33 / Q9BYT3* / serine/threonine kinase 33*	ENSMUSG00000031027	26
Dcx / O88809 / Neuronal migration protein doublecortin / O43602* / doublecortin*	ENSMUSG00000031285	2

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR002291	Phosphorylase kinase, gamma catalytic subunit
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR017441	Protein kinase, ATP binding site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0005975	carbohydrate metabolic process	IEA
biological_process	GO:0005977	glycogen metabolic process	IBA
biological_process	GO:0005978	glycogen biosynthetic process	IEA
biological_process	GO:0006468	protein phosphorylation	IEA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0018105	peptidyl-serine phosphorylation	IBA
biological_process	GO:0018107	peptidyl-threonine phosphorylation	IBA
biological_process	GO:0035556	intracellular signal transduction	IBA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005964	phosphorylase kinase complex	IBA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IEA
molecular_function	GO:0004689	phosphorylase kinase activity	IBA
molecular_function	GO:0005516	calmodulin binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0019899	enzyme binding	IEA

Pathways (from Reactome)

Pathway description

Glycogen breakdown (glycogenolysis)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002608	increased hematocrit	"greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0003131	increased erythrocyte count	"greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0005564	increased hemoglobin content	"increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Padi6^{tm1b(KOMP)Wtsi}/Padi6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Padi6^{tm1b(KOMP)Wtsi}/Ucd
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Nphp1^{tm1.1(KOMP)Vlcg}/Nphp1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Nphp1^{tm1.1(KOMP)Vlcg}/Ucd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000036879	Phkb / Q7TSH2 / Phosphorylase b kinase regulatory subunit beta / Q93100* / phosphorylase kinase regulatory subunit beta*	/ complex
ENSMUSG00000021069	Pygl / Q9ET01 / Glycogen phosphorylase, liver form / P06737* / glycogen phosphorylase L*	/ reaction
ENSMUSG00000030815	Phkg2 / Q9DB30 / Phosphorylase b kinase gamma catalytic chain, liver/testis isoform / P15735* / phosphorylase kinase catalytic subunit gamma 2*	/ complex
ENSMUSG00000001175	Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*	/ complex
ENSMUSG00000031295	Phka2 / Q8BWJ3 / Phosphorylase b kinase regulatory subunit alpha, liver isoform / P46019* / phosphorylase kinase regulatory subunit alpha 2*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr