ENSMUSG00000028078


Mus musculus

Features
Gene ID: ENSMUSG00000028078
  
Biological name :Dclk2
  
Synonyms : Dclk2 / Q6PGN3 / Serine/threonine-protein kinase DCLK2
  
Possible biological names infered from orthology : doublecortin like kinase 2 / Q8N568
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 86786151
Gene end: 86920852
  
Corresponding Affymetrix probe sets: 10499138 (MoGene1.0st)   1428222_at (Mouse Genome 430 2.0 Array)   1456025_at (Mouse Genome 430 2.0 Array)   1458488_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141816
Ensembl peptide - ENSMUSP00000141707
Ensembl peptide - ENSMUSP00000141866
Ensembl peptide - ENSMUSP00000142267
Ensembl peptide - ENSMUSP00000029719
Ensembl peptide - ENSMUSP00000141567
NCBI entrez gene - 70762     See in Manteia.
MGI - MGI:1918012
RefSeq - XM_017319719
RefSeq - XM_006502072
RefSeq - XM_006502073
RefSeq - XM_006502074
RefSeq - XM_006502075
RefSeq - XM_006502076
RefSeq - XM_006502077
RefSeq - XM_006502078
RefSeq - XM_011240226
RefSeq - XM_011240227
RefSeq - XM_017319718
RefSeq - NM_001195496
RefSeq - NM_001195497
RefSeq - NM_001195498
RefSeq - NM_001195499
RefSeq - NM_001195500
RefSeq - NM_027539
RefSeq - XM_006502065
RefSeq - XM_006502066
RefSeq - XM_006502067
RefSeq - XM_006502068
RefSeq - XM_006502069
RefSeq - XM_006502070
RefSeq - XM_006502071
RefSeq Peptide - NP_001182426
RefSeq Peptide - NP_001182428
RefSeq Peptide - NP_001182429
RefSeq Peptide - NP_081815
RefSeq Peptide - NP_001182425
RefSeq Peptide - NP_001182427
swissprot - A0A0A6YX33
swissprot - A0A0A6YX71
swissprot - Q6PGN3
swissprot - A0A0A6YWI6
Ensembl - ENSMUSG00000028078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dclk2aENSDARG00000034093Danio rerio
 DCLK2ENSGALG00000032386Gallus gallus
 DCLK2ENSG00000170390Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dclk1 / Q9JLM8 / Mus musculus doublecortin-like kinase 1 (Dclk1), transcript variant 12, mRNA. / O15075* / doublecortin like kinase 1*ENSMUSG0000002779765
Dcx / O88809 / Neuronal migration protein doublecortin / O43602* / doublecortin*ENSMUSG0000003128533
Dclk3 / Q8BWQ5 / Serine/threonine-protein kinase DCLK3 / Q9C098* / doublecortin like kinase 3*ENSMUSG0000003250029
Stk33 / Q924X7 / Serine/threonine-protein kinase 33 / Q9BYT3* / serine/threonine kinase 33*ENSMUSG0000003102718
Phkg2 / Q9DB30 / Phosphorylase b kinase gamma catalytic chain, liver/testis isoform / P15735* / phosphorylase kinase catalytic subunit gamma 2*ENSMUSG0000003081516
Phkg1 / P07934 / Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform / Q16816* / phosphorylase kinase catalytic subunit gamma 1*ENSMUSG0000002553716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003533  Doublecortin domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR036572  Doublecortin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0021766 hippocampus development IGI
 biological_processGO:0021860 pyramidal neuron development IGI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:1900181 negative regulation of protein localization to nucleus IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008262 abnormal hippocampus region morphology "any structural anomaly of a part or parts of the hippocampus that have a particular function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008267 abnormal hippocampus CA3 region morphology 
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008285 abnormal hippocampus granule cell layer 
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dclk2tm1.2Jgg/Dclk2tm1.2Jgg,Dcxtm1Caw/Y
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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