ENSG00000170390


Homo sapiens

Features
Gene ID: ENSG00000170390
  
Biological name :DCLK2
  
Synonyms : DCLK2 / doublecortin like kinase 2 / Q8N568
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.23
Gene start: 150078274
Gene end: 150257457
  
Corresponding Affymetrix probe sets: 216724_at (Human Genome U133 Plus 2.0 Array)   216725_at (Human Genome U133 Plus 2.0 Array)   227666_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427235
Ensembl peptide - ENSP00000401916
Ensembl peptide - ENSP00000489372
Ensembl peptide - ENSP00000489465
Ensembl peptide - ENSP00000296550
Ensembl peptide - ENSP00000303887
NCBI entrez gene - 166614     See in Manteia.
OMIM - 613166
RefSeq - XM_017007833
RefSeq - NM_001040260
RefSeq - NM_001040261
RefSeq - XM_005262785
RefSeq - XM_005262786
RefSeq - XM_017007832
RefSeq Peptide - NP_001035351
RefSeq Peptide - NP_001035350
swissprot - A0A0U1RRD0
swissprot - G5E9L9
swissprot - Q8N568
swissprot - A0A0U1RR70
Ensembl - ENSG00000170390
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dclk2aENSDARG00000034093Danio rerio
 DCLK2ENSGALG00000032386Gallus gallus
 Dclk2ENSMUSG00000028078Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DCLK1 / O15075 / doublecortin like kinase 1ENSG0000013308364
DCX / O43602 / doublecortinENSG0000007727932
DCLK3 / Q9C098 / doublecortin like kinase 3ENSG0000016367326
STK33 / Q9BYT3 / serine/threonine kinase 33ENSG0000013041318
PHKG1 / Q16816 / phosphorylase kinase catalytic subunit gamma 1ENSG0000016477615
PHKG2 / P15735 / phosphorylase kinase catalytic subunit gamma 2ENSG0000015687315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003533  Doublecortin domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR036572  Doublecortin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0021860 pyramidal neuron development IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:1900181 negative regulation of protein localization to nucleus IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr